Creative Biolabs is a leading service provider that focuses on polyclonal, monoclonal, and recombinant antibody development for research, diagnosis, and potential therapeutics. Based on our extensive experience and state-of-the-art platforms, Creative Biolabs now offers a series of biomarker-specific IVD (in vitro diagnostic) antibody development services to clients globally. Especially, we introduce our IVD antibody development services for dendritic cell (DC).
General Introduction of Dendritic Cell
Arising from bone marrow progenitors, DCs could produce circulating DC precursors that seed the peripheral tissues as immature cells. DCs, antigen-presenting cells, play an essential role in the immune response by linking the innate and adaptive immunity. DCs are present in all the tissues of the human body and exist predominantly in an antigen-capturing state, which maintains immunologic tolerance by routinely migrating to the draining lymph nodes and presenting self-antigens to lymphocytes in a tolerogenic manner. Along with many phenotypical and functional changes, the maturation or activation of DCs promotes the migration to lymph nodes, the secretion of cytokines, and resulting in the activation of T cells. Glucocorticoids (GCs) are steroid hormones that play key roles in a variety of essential cardiovascular, metabolic, and homeostatic functions and play a role in the regulation of sepsis and reduce sepsis by diminishing dendritic cell responses.
Fig. 1 GCs act on dendritic cells to ameliorate endotoxin-induced sepsis.
Dendritic Cells in Sepsis
In recent years, sepsis has been a leading cause of death for critically ill patients. Many reports have shown that abnormalities in DC homeostasis are involved in a variety of human diseases, including infections. DCs play a pivotal role in the immune activation and survival in sepsis. In the process of sepsis, the number of DCs, the differentiation of monocytes into DCs, and the levels of surface molecules associated with the function of DCs are changed. Many mechanisms involved in the alterations of DCs during sepsis, such as the induction of apoptosis, reactive oxygen species generation, activation of the Wnt signaling pathway, epigenetic regulation, and variation in Toll-like receptor-dependent signaling. In this review, we present the classifications of DC subsets and mechanisms involved in the alterations of DCs in sepsis, as well as further discuss the therapeutic strategies targeting DCs in sepsis to improve the aberrant immune response and prolong the life during sepsis progression.
IVD Antibody Development Services for Dendritic Cell
In order to render more precise antibody-based diagnostic tools and assist clinicians in the diagnosis, prognosis, and staging of sepsis diseases, Creative Biolabs is providing customized IVD antibody development services to produce high-quality antibodies for diagnostic usage. We are confident that our commitment to science and research will enable us to offer you the best products and services. If you are interested in our services, please feel free to contact us for more detailed information.
Reference
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