As a world-leading service provider of antibody development and generation, Creative Biolabs is ready to provide a whole series of biomarker-specific in vitro diagnostic (IVD) antibody development services. A team of experienced scientists focused on antibody development are pleased to assist you in your project in a timely and cost-effective manner. Here, we introduce our IVD antibody development services targeting platelet-derived growth factor (PDGF-BB).
Platelet-Derived Growth Factor (PDGF-BB)
Platelet-derived growth factor (PDGF) is one of numerous growth factors. It regulates cell growth and division. In particular, PDGF plays a significant role in blood vessel formation, the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes, vascular smooth muscle cells and mesenchymal stem cells as well as chemotaxis, the directed migration, of mesenchymal cells. PDGF is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF-BB), or one of each (PDGF-AB).
PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. PDGF also plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblasts, a type of connective tissue cell that is especially prevalent in wound healing.
Fig. 1 Human platelet-derived growth factor BB monomer.1
PDGF-BB Marker of Sepsis Infections
Vascular permeability increases in response to systemic inflammation mediated by endotoxin and various cytokines. Macrophages and lymphocytes can produce VEGF. VEGFs are involved in wound healing, cardiovascular diseases, tumor growth and progression, ocular neovascularization and inflammatory diseases such as rheumatoid arthritis. In particular, VEGF-A acts on endothelial cells, causing vasodilatation by induction of endothelial nitric oxide synthase. VEGF-A also has antiapoptotic effects on endothelium. More importantly, VEGF-A was found to be an important mediator of vascular permeability. Also, VEGF is a potent hypoxia-induced mediator in the formation of new capillaries (angiogenesis). VEGF-induced angiogenesis was also found to play an important role in the etiology of several additional diseases associated with abnormal angiogenesis as tumor angiogenesis and in wound repair.
The admission VEGF is a useful marker for the evaluation of septic patients. PDGF-BB has been shown to promote the structural integrity of the vessel wall and to increase wound healing capacity. The ability of rhAPC to upregulate endothelial PDGF-BB production may represent a new molecular mechanism by which rhAPC controls vessel wall homeostasis and increases tissue healing capacity in severe sepsis. PDGF-BB may serve as useful laboratory marker to predict survival in patients presenting with severe sepsis.
IVD Antibody Development Service Targeting PDGF-BB Marker
In recent years, IVD technology is undergoing rapid development. IVD antibodies that are specific to disease markers have been widely used in immunodiagnostic tools to aid in the diagnosis of various diseases, conditions, and infections. With years of experience and advanced technology, Creative Biolabs is able to provide a full range of high-quality and cost-effective IVD antibody development services. Especially, we help develop novel anti-PDGE-BB antibodies for your IVD projects.
Please feel free to contact us for detailed information.
Reference
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