As a preeminent contract antibody development company, Creative Biolabs offers high-quality in vitro diagnostic (IVD) antibody development services targeting a wide range of biomarkers. Here, we focus on the lactate marker of sepsis. We are committed to providing the highest quality of custom services and products at the most reasonable prices.
Introduction of Lactate
Lactate is an essential, versatile metabolic fuel in cellular bioenergetics with 2 stereoisomers: L-lactate and D-lactate. Being the predominant physiologic enantiomer, L-lactate accounts for 95% to 99% of total body lactate in health. Generally, plasma lactate concentration depends on the balance between production and consumption. In health, most tissues can both produce and consume lactate. The main lactate producers are skeletal muscle (40%) and skin but include other tissues such as intestine, brain, renal medulla, erythrocytes, leukocytes, and platelets. Once formed, lactate can either be used within the same cell or transported out of the cell via proton-linked and sodium-coupled monocarboxylate transporters (MCTs). However, lactate consumption occurs primarily in the liver, with important contributions from the renal cortex and myocardium. In other words, the liver can metabolize up to 50% to 70% of all lactate consumed and the renal cortex can metabolize 25% to 30%.
Fig.1 Role of lactate in cancer.1, 2
Lactate Marker of Sepsis
Lactate is an important physiologic metabolite acting as an alternative energy source and limits the acidosis caused by ATP hydrolysis. Lactate production is a protective response to allow cells to survive despite tissue hypoperfusion or hypoxia. It has been reported that increased lactate level is closely associated with the severity of many life-threatening problems but is not the cause. What's more, studies have suggested that the presence of an elevated serum lactate level is strongly associated with morbidity and mortality in diverse populations of critically ill patients, especially for patients with severe sepsis presenting to the emergency department (ED), which may be due to either impaired lactate clearance or excessive production. In this case, the serum level of lactate can be used as a specific marker for the detection of sepsis.
IVD Antibody Development Services for Lactate Marker
With the rapid development of IVD technology, IVD antibodies have been used as important tools for the detection of numerous diseases, conditions, or infections. Through our role as a leading antibody service provider, Creative Biolabs is well-positioned to develop high-quality anti-lactate antibodies. Besides antibody generation, Creative Biolabs also offers diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, assay optimization, and kit production.
Creative Biolabs has successfully completed numerous IVD antibody generation and development projects for clients across the globe. If you are interested in the services we provide, please feel free to contact us and get a quote.
References
For Research Use Only.
