Creative Biolabs is one of the leading customized antibody generation and development providers. We specialize in the generation of antibodies against a wide range of targets for R&D, diagnostic, and therapeutic applications. Currently, we have launched a series of in vitro diagnostic (IVD) antibody development services targeting numerous diagnostic biomarkers of human diseases. Here, we focus on the IL-2 as a marker of sepsis.
IL-2 Signaling Pathways
Interleukin-2 (IL-2) is an O-glycosylated four alpha-helix bundle cytokine that is primarily produced by activated T cells, dendritic cells, and B cells. The biological activity of IL-2 is mediated by binding to a cell surface receptor complex consisting of IL-2R alpha/CD25, IL-2/IL-15R beta, and the common gamma-chain/IL-2R gamma subunit. IL-2 can also bind with low affinity to IL-2R alpha alone or with intermediate affinity to a complex consisting of IL-2/IL-15 R beta and the common gamma-chain subunit. Functionally, IL-2 induces the expression of both IL-2 and IL-2R alpha on activated CD4+ and CD8+ T cells and stimulates their proliferation. In contrast, IL-2 also plays an important role in the maintenance of peripheral self-tolerance both by initiating Fas-mediated activation-induced cell death of CD4+ T cells following antigen restimulation and by its ability to promote the differentiation and survival of regulatory T cells. Rather than displaying a severe immunodeficient phenotype, mice lacking IL-2, IL-2R alpha, or IL-2R beta accumulate activated T lymphocytes, have reduced numbers of regulatory T cells, and develop autoimmune diseases. This suggests that the maintenance of T cell homeostasis and prevention of self-reactivity is the primary function of IL-2 signaling. In addition, IL-2 may enhance the cytotoxicity of natural killer cells and be required for B cell proliferation and immunoglobulin production.
Fig.1 Interaction of IL-2 with its receptor and downstream signaling pathways.1
IL-2 is an important marker for the diagnosis of sepsis. IVD antibodies for the IL-2 marker are useful for the diagnosis of sepsis. Through our role as a leading antibody service provider, Creative Biolabs is well-positioned to deliver high-quality IVD antibody development services targeting IL-2 marker. Besides antibody generation, Creative Biolabs also offers diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, assay optimization, and kit production.
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Reference
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