IVD Antibody Development Services for Leptin Marker

Creative Biolabs is a leading service provider that focuses on polyclonal, monoclonal, and recombinant antibody development for research, diagnosis, and potential therapeutics. Based on our extensive experience and state-of-the-art platforms, Creative Biolabs now offers a series of biomarker-specific IVD (in vitro diagnostic) antibody development services to clients globally. Especially, we introduce our IVD antibody development services for leptin marker. We are confident that our commitment to science and research will enable us to offer you the best products and services.

Introduction of Leptin

Leptin, which is described as the hormone of energy expenditure, belongs to the family of long-chain helical cytokines, including leukemia inhibitory factor, ciliary neurotrophic factor (CNTF), and human growth hormone, based on its crystal structure. The lep gene where leptin derives from is highly preserved across mammals, and leptin orthologs exist in amphibians, reptiles, and fish with considerable divergence in primary amino acid sequences. As a hormone that has the ability to regulate energy balance by inhibiting hunger, leptin is predominantly produced and secreted from adipose tissue into the circulation. Circulating leptin levels positively reflect adipose tissue size, and communicate energy storage status to the brain. In addition, the expression and secretion of leptin can be regulated by many factors, such as inflammatory cytokines, glucocorticoids, and insulin.

Fig.1 A schematic diagram reveals leptin-mediated appetite suppression and energy expenditure. (Inagaki-Ohara, 2019) Fig.1 Adipocyte-derived leptin modulates the suppression of appetite and increased energy expenditure mediated by leptin signaling in hypothalamu.^{1, 2}

Leptin Marker of Sepsis

Sepsis is a systemic inflammatory reaction which is triggered by an infective agent, such as bacteria, viruses, fungi or parasites. Severe sepsis may result in systemic inflammation, multi-organ failure, and septic shock. Infections and sepsis are accompanied by clinical signs such as leukocytosis, changes in body temperature and the development of tachycardia. However, these classic indicators of systemic inflammation are neither sensitive nor specific for sepsis. Therefore, early markers are useful for the diagnosis and treatment of sepsis. In recent years, studies have suggested that the serum leptin concentrations of patients with sepsis were significantly higher than that of normal people. What's more, it has also been demonstrated that leptin, in combination with other independent factors, such as temperature, platelet and WBCs and heart rate, may be an effective diagnostic model of sepsis. Under this condition, the serum level of leptin can be used as a specific marker for the diagnosis of sepsis.

Fig.2 Schematic diagram of the Leptin receptor signaling pathway. (Inagaki-Ohara, 2019) Fig.2 Leptin receptor signaling.^{1, 2}

IVD Antibody Development Services for Leptin Marker

In the past years, IVD antibodies have been widely used as important tools for the detection of numerous diseases and infections. As a professional company in antibody development, Creative Biolabs provides a full range of biomarker-specific IVD antibody development services and diagnostic immunoassay development services. Along with over a decade of rich experience in providing excellent custom services for IVD antibody discovery, our services can totally meet your special requirements.