Creative Biolabs is a world-leading service provider of application-specific antibody development. Here, we introduce our in vitro diagnostic (IVD) antibody development and immunoassay development services targeting the ceramide marker. We are confident that our commitment to science and research will enable us to offer you the best products and services.
General Description of Ceramide
Ceramides are composed of a long-chain or sphingoid base linked to a fatty acid via an amide bond. Ceramides play an important role not only as structural elements but also as regulators of a variety of cellular processes including differentiation, inflammation, proliferation, and apoptosis. Recent data indicate that ceramide (Cer) and lysophosphatidylcholine (LPC) regulate immune cell functions. Since these bioactive lipids are generated in blood plasma by inflammatory lipases, we hypothesized that they may be involved in the process of acute systemic sepsis.
Fig.1 2D Structure of Ceramide.
Assessment of Ceramide Marker Abnormalities in Sepsis
Acute septic shock and severe sepsis are common in intensive care units. ω-3 and ω-6 fatty acids, eicosanoids, LPC, and ceramide seem to play a significant role in sepsis. Cytokines and lipids interact with each other that may have relevance to their role in sepsis and its outcome. Ceramide has a significant role in ARDS. Hence, it is important to study the exact interaction between cytokines, free radicals, ceramide, LPC and other lipids and their specific roles in sepsis. Such knowledge helps to devise better methods of management of patients with acute septic shock and severe sepsis to improve their recovery. Activation of phospholipase A2, excess formation of proinflammatory eicosanoids, decreased generation of lysophosphatidylcholine (LPC) and enhanced levels of ceramide play a significant role in sepsis. This suggests that lipids participate in the pathogenesis of sepsis.
Fig. 1 Role of the ceramide in apoptosis.1,2
IVD Antibody Development for Ceramide Marker
IVD antibodies are extensively applied for disease diagnosis, therapeutic monitoring, and guiding the use of targeted therapies. Various immunoassay formats that are based on the use of IVD antibodies can be used to detect the disease marker, such as immunohistochemistry, lateral flow assay, and sandwich ELISA. Creative Biolabs offers high-quality IVD antibody development services and immunoassay development services targeting the ceramide marker.
Creative Biolabs has successfully completed numerous IVD antibody generation and development projects for clients across the globe. If you need more information, please do not hesitate to contact us for more details.
References
For Research Use Only.
