3D Ex Vivo Human Tertiary or Lower Airways (Diseased) Model Introduction

Overview of Lower Airways

The airways are a vital component of the respiratory system and play a crucial role in gas exchange. The airway consists of two main parts: the upper and lower airways. The upper respiratory tract includes the nose, sinuses, and pharynx. The major passages and structures of the lower airway include the trachea, bronchi, bronchiole, and alveoli. The lower respiratory tract has been implicated in many diseases such as asthma, emphysema, pneumonia, and tuberculosis. Currently, the understanding of human respiratory disease primarily relies on animal models. The development of effective ex vivo models can complement animal models to facilitate the understanding of pathological mechanisms and the development of effective therapeutics.

Limitations of Common Models

Fig.1 Weaknesses of the models. (Creative Biolabs)

What Makes a Good Lower Airways (Diseased) Model?

Applications

Fig.2Application field. (Creative Biolabs)

What Can We Do?

At Creative Biolabs, in addition to healthy tertiary or lower airways, we can also source tissues from donors with asthma. With our robust models, we can confidently develop a reasonable protocol for your reference compounds of interest to explore their bronchial effects. Please contact us in time for detailed information and professional suggestion. In addition to 3D ex vivo human tertiary or lower airways (diseased) model, we have also developed the following ex vivo models. For more details of our models, Please click the following link below.

• 3D Ex Vivo Secondary Airways (healthy) Contractility Model
• 3D Ex Vivo Secondary Airways (diseased) Contractility Model
• 3D Ex Vivo Human Tertiary or Lower Airways (Healthy) Model
• 3D Ex Vivo Human Tertiary or Lower Airways (Bronchodilation) Model

Related Sections:

• Ex Vivo Precision-Cut Lung Slice (PCLS) Model
• Ex Vivo Pulmonary Artery Bath Model
• Ex Vivo Airway Contractility Model