3D Ex Vivo Human Tertiary or Lower Airways (Healthy) Model Introduction

Characteristics of Healthy Human Tertiary or Lower Airways?

In humans, the third or lower airway refers to the bronchioles that line the lungs. They can efficiently distribute air to the alveoli, remove foreign particles from the air, and facilitate gas exchange with the blood between the lungs and the blood. A healthy third or lower airway has several key characteristics.

Based on the above key characteristics, the use of healthy third or lower airways can help researchers isolate the specific effect of the drug on bronchoconstriction or dilation without confounding factors that may exist in airway disease or injury models. Creative Biolabs provide 3D ex vivo human tertiary or lower airways (healthy) model to assist customers in their drug development process.

3D Ex Vivo Human Tertiary or Lower Airways (Healthy) Model

3D ex vivo human tertiary or lower airways is a model dedicated to the study of the lower respiratory tract or bronchioles. The model is created by harvesting the third or lower airway from a donor and maintaining it in a culture environment that mimics the internal conditions of the human body. The model is made up of multiple components that work together to form a functional breathing system. These components include airway epithelium, extracellular matrix (ECM), immune cells, and smooth muscle cells.

For the drug efficacy evaluation, our professional technical team will use an electromyography system to measure the degree of bronchoconstriction or dilation on your candidate drug.

Advantages of 3D Ex Vivo Human Tertiary or Lower Airways (Healthy) Model

Currently, we can provide the following models depending on the effector that causes bronchiectasis.

• 3D Ex Vivo Human Acetylcholine Receptor Model
• 3D Ex Vivo Human Prostanoid Receptor Model
• 3D Ex Vivo Human Lipoxin, Eicosanoids and Resolvin E1

The 3D ex vivo human tertiary or lower airways (healthy) model provided by Creative Biolabs is mainly used to develop new drugs or treatments for respiratory diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis. If you have been looking for a suitable healthy airway model to test the ability of new drugs or therapies to induce bronchoconstriction or dilation, please contact us. In addition, we can also provide other 3D ex vivo airway contractility models.

• 3D Ex Vivo Human Secondary Airways (Healthy) Contractility Model
• 3D Ex Vivo Human Secondary Airways (Diseased) Contractility Model
• 3D Ex Vivo Human Tertiary or Lower Airways (Diseased) Model
• 3D Ex Vivo Human Tertiary or Lower Airways (Bronchodilation) Model

Related Sections:

• Ex Vivo Precision-Cut Lung Slice (PCLS) Model
• Ex Vivo Pulmonary Artery Bath Model
• Ex Vivo Airway Contractility Model