3D Ex Vivo Human Trachea Tissue Model Introduction

The trachea is an integral part of the respiratory system and its main function is to carry air in and out of the lungs. Most studies of human tracheal infection rely on established cell lines and animal models. However, experimental results obtained from these studies may not fully reflect the complex molecular events occurring in the human trachea in vivo.

Weaknesses of Common Models

Traditional models have several limitations in the study of complex tracheal infections.

Cell models

Animal models

Cannot simulate complex interactions in vivo.
Isolated cell populations may not accurately represent the dynamics that occur between different structural cells and inflammatory cells.
Results obtained from cell lines containing only a single cell type cannot represent the complex structure and immune response in the human airway.

Due to species differences, animal experiments cannot completely reflect the real situation of the human body.
Animal models are constrained by price and ethics.
Differences between the animal and human immune systems can affect the translation of results obtained in animals to human pathophysiology.
Some susceptible species cannot fully mimic human infection due to limitations of multiple factors.

Fig.1 Limitations of conventional models. (Creative Biolabs)

Why Choose Ex vivo Models

There are a variety of cell types as well as differentiation states in ex vivo models.
Ex vivo models can simulate the physiological microenvironment of the intact trachea.
Ex vivo models provide insight into the intricate connections between cells and the extracellular matrix in intact tissues.
This ex vivo model may provide a new perspective for further study of the entire respiratory system.
These models allow the preservation of in vivo tissue characteristics.

Applications

Fig.2 Common Applications. (Creative Biolabs)

Creative Biolabs is a world leading CRO and recognized ex vivo model provider. Decades of market experience and comprehensive ex vivo models power your preclinical drug development. In addition to our diverse range of models, we also welcome special requests from customers. Please contact us in time for more details.

More information on the models can be obtained through the links below:

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

3D Ex Vivo Human Trachea Tissue Model Introduction

Weaknesses of Common Models

Why Choose Ex vivo Models

Applications

Related Sections: