Cardiotoxicity Evaluation by Ex Vivo Human Cardiovascular Tissue Model

Human cardiac tissue consists of a complex mixture of endothelial cells, fibroblasts, and neurons, along with a specific extracellular matrix protein array. The intricate structure poses limitations to the reliability of drug and compound cardiac toxicity predictions. In order to address this challenge, Creative Biolabs offers ex vivo human cardiovascular tissue model, providing scientists with accurate, reliable, and highly correlated cardiac toxicity assessment services.

Ex vivo Human Cardiovascular Tissue-Based Cardiotoxicity Evaluation

Comprehensive Structural Model
Our tissue samples maintain the integrity of the human cardiac structure, encompassing the intricate cellular composition and precise cardiac physiological environment.
Expanded Functional Evaluation
Our approach allows for toxicity assessments to be extended to the level of the entire organ, providing crucial insights into aberrant myocardial calcium handling characteristics.
3D Cardiotoxicity Research
Employing a perfusion system and organ bath, our model simulates altered mechanical stretching, electrophysiological properties, and heart rate features.

Why Use Ex vivo Human Tissue Models?

In the process of developing therapeutic compounds, less than 10% of candidate compounds successfully transition from clinical testing to market approval. This statistic underscores the inadequacy of both in vitro cell culture models and in vivo animal models in simulating heart diseases and predicting compound reactions.

Due to the limited correlation and scalability of traditional models, there has been a persistent lack of a reliable and accurate predictive system for adult cardiac physiology and toxicology. By utilizing our ex vivo human cardiovascular tissue model, Creative Biolabs offers a robust and precise alternative for conducting studies on the human heart outside the body.

What We Provide?

At Creative Biolabs, we are committed to providing our clients with comprehensive, cutting-edge, one-stop services tailored to your specific requirements.

Model acquisition:

With adherence to ethical and regulatory procedures, we collect human cardiovascular tissue samples that are subsequently arrested and appropriately preserved. Our global supply network ensures us to be the optimal choice for accessing these invaluable resources.

Cardiac toxicity assessment:

We provide targeted investigations into mechanical attributes using three-dimensional mechanical loading, electrophysiological studies, and a comprehensive range of detection methods such as immunostaining, MTT assays, and glucose utilization measurements.

Compound screening:

Our foundational screening library encompasses hundreds of commonly used compounds and their derivatives. To determine your specific testing requirements and sample submission format, please consult with our service team.

Selectable Options

Creative Biolabs is steadfast in our commitment to deliver high-quality models that faithfully replicate human cardiac physiology and pathology. Through these cutting-edge models, we conduct highly sensitive and specific pharmacological intervention assays and cardiac toxicity predictions.

Cardiotoxicity Evaluation by Cardiac Organoid Model

Cardiotoxicity Evaluation by Precision-Cut Human Heart Slice Model

Cardiotoxicity Evaluation by 3D Cardiac Spheroid Model

Cardiotoxicity Evaluation by Ex vivo Human Cardiovascular Tissue Model

Cardiotoxicity Evaluation by iPSC-derived Cardiomyocytes

hERG Safety Evaluation

With our 3D biology technology platform, Creative Biolabs endeavors to satisfy any biological needs. Please do not hesitate to contact us for any requirements.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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