Cardiotoxicity Evaluation by Cardiac Organoid Model

In late-stage clinical drug trials, cardiac toxicity poses a monumental financial burden on the drug development process. Creative Biolabs takes great pride in introducing the cardiac organoid model. This extraordinary advancement enables a remarkably faithful in vitro simulation of human organ function with efficacious cardiotoxicity evaluation services.

Advantages of Creative Biolabs' Cardiac Organoid

Preclinical evaluation of drug response and toxicity is often conducted using non-representative traditional 2D cultures or non-translatable animal models. The limited availability of samples and the difficulty in mastering specialized techniques further restrict the application of these models.

Our innovative cardiac organoid stands as a more potent tool for cardiotoxicity evaluation. By fabricating human cardiac organoids using cells with specific genotypes and phenotypes, we dramatically enrich our biological comprehension and foster heightened assurance in the translational potential of research outcomes in the realm of human subjects.

Cardiac organoids. (Zhao, 2021) Cardiac organoids.¹

Key Features

Well-constructed 3D tissue mimics exhibit a wide range of physiological organ functions as well as pathologies.
Cardiac organoids maintain crucial survival signaling cues, enabling possibilities for long-term culture and drug testing.
The natural 3D microenvironment reproduces more drug stimulation responses and pathological reactions for further investigation.

Comprehensive Solutions at Your Disposal

At Creative Biolabs, we offer more than mere organoid models – our commitment lies in providing tailor-made, ingenious one-stop solutions.

Cardiac Organoids Fabrication
Our methodology commonly relies on employing cell lineages induced from hiPSCs for organoid construction, expanding the availability of easily obtainable cell sources. Other available cells, including adult stem cells, primary cells, or immortalized cell lines, can also be used.
Gene Editing Technology
Leveraging the power of genome editing techniques empowers us to customize cardiac organoid models by introducing specific gene mutations of interest or rectifying known mutations to restore cellular physiological functionality.
Multifaceted Endpoint Detection
We perform testing with any desired endpoint format, including electrophysiological detection, impedance-based real-time biosensing, RNA sequencing, biomarker gene expression analysis, calcium transient analysis, and imaging/algorithm-based analysis.

Our Comprehensive Offerings

Creative Biolabs is committed to delivering comprehensive services for cardiotoxicity evaluation. Rest assured, our in vitro model-based testing services exude unparalleled confidence when it comes to accommodating your exacting experimental arrangements and result-oriented requisites.

Cardiotoxicity Evaluation by Cardiac Organoid Model

Cardiotoxicity Evaluation by Precision-Cut Human Heart Slice Model

Cardiotoxicity Evaluation by 3D Cardiac Spheroid Model

Cardiotoxicity Evaluation by Ex vivo Human Cardiovascular Tissue Model

Cardiotoxicity Evaluation by iPSC-derived Cardiomyocytes

hERG Safety Evaluation

Our Services

Relying on our state-of-the-art biological research platform, Creative Biolabs expert team thrives on accommodating and addressing the most intricate requests, allowing us to devise adaptable experimental plans that cater to an extensive range of needs, please feel free to contact us for any needs.

References

Lewis, L.; et al. Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease. Nature. 2021, 1038: 25329.
Zhao, D.; et al. Cardiac organoid - a promising perspective of preclinical model. Stem Cells Research and Therapy. 2021, 12: 272.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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Research Model

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