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Cardiotoxicity Evaluation by Precision-Cut Human Heart Slice Model

Unexpected cardiac toxicity has led to the exclusion of numerous potential therapeutic compounds at the clinical stage. In order to provide a reliable human cardiac model for preclinical drug testing, Creative Biolabs introduces the precision-cut human heart slice model, which enables accurate and standardized rapid drug cardiotoxicity testing.

Precision-cut Human Heart Slice

Through close collaboration with esteemed medical institutions and renowned donation organizations worldwide, Creative Biolabs procures adult human cardiac tissue samples in accordance with rigorous ethical and regulatory protocols. These samples undergo an optimized processing procedure to obtain precise thin slices.

Pseudo 3D structure The cardiac slices retain the multicellularity and extracellular structure of adult cardiac tissue, accurately replicating the human cardiac physiological environment in specific regions.
High in vitro activity Our cardiac slices have demonstrated long-term high viability and functionality in culture, obtaining nutrients directly from the culture medium.
Pharmacological reactions The typical cardiac tissue structure allows the cardiac slices to preserve the contractility, calcium handling characteristics, and conduction velocity of the original tissue.

Why Choose Creative Biolabs?

Our standardized model construction and cardiotoxicity evaluation procedures enable accurate prediction and comprehensive evaluation of the anticipated cardiotoxicity and drug response for various compounds. Opting for our services grants you access to:

  • Stable and homogeneous cardiac tissue slices
  • High-throughput multi-endpoint testing
  • Optimized proprietary culture media and electrical stimulation protocols
  • Optional mechanical loading procedures
  • 24-hour technical support

Optional Evaluation Approaches

Through various downstream analysis procedures, our system supports the acquisition of diverse clinically relevant information, including accurate transcription profiles, calcium homeostasis, electrophysiology, protein expression, or contractility measurements (biomechanical curves). In addition, we offer in vitro cardiotoxicity evaluation services based on other types of models, providing personalized and focused predictive programs for your research projects.

Cardiotoxicity Evaluation by Cardiac Organoid Model

Cardiotoxicity Evaluation by Precision-Cut Human Heart Slice Model

Cardiotoxicity Evaluation by 3D Cardiac Spheroid Model
Cardiotoxicity Evaluation by Ex vivo Human Cardiovascular Tissue Model
Cardiotoxicity Evaluation by iPSC-derived Cardiomyocytes
hERG Safety Evaluation

Our Services

In addition to providing related services for cardiac toxicity identification, Creative Biolabs also offers a range of research models and related services based on 3D in vitro biology, assisting in your biological, pathological, or drug screening research. Contact us today for any needs, and our team of experts will provide you with comprehensive solutions.

Reference

  1. Wang, K.; et al. Cardiac tissue slices: preparation, handling, and successful optical mapping. Am J Physiol Heart Circ Physiol. 2015, 308: 1112-1125.
Research Model
3D Biology Based Biomarker Discovery
Based Biomarker Discovery
3D Biology Based Drug Discovery and Development
Based Biomarker Discovery
3D Biology Based Toxicity Evaluation
Based Biomarker Discovery
Supporting Assays
Based Biomarker Discovery

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