3D Ex Vivo Human Acetylcholine Receptor Model Introduction

Acetylcholine (ACh) is a common parasympathetic neurotransmitter that plays a vital role in the regulation of airway smooth muscle contraction, airway remodeling and mucus production. It is worth noting that accumulating evidence indicates that Ach is closely related to the pathophysiology of obstructive airway diseases. Like many other ligand-activated neurotransmitter receptors, ACh receptors (AChRs) consist of two major subtypes: metabotropic muscarinic receptors and ionotropic nicotinic receptors.

Fig.1 Different types of AChRs. (Creative Biolabs)

Human ACh Receptor Model

In this model, we used ACh as a reference compound to assess whether a compound of interest induces bronchoconstriction in the airways of healthy humans. The airways we use are initially processed through a proprietary procedure to ensure functionality. This provides a powerful platform for the development of new drugs treating tracheal diseases.

Our Capabilities

As a world-leading supplier of ex vivo human tissue models, Creative Biolab is committed to providing diverse and first-class ex vivo models for your respiratory disease research. Our vision is to help you make great breakthroughs in the field. If you have any questions in the research of lower airway diseases, please contact our professional team for customized solutions and reasonable advice.

Related Sections:

• Ex Vivo Secondary Airways (Healthy) Contractility Model
• Ex Vivo Secondary Airways (Diseased) Contractility Model
• Ex Vivo Tertiary or Lower Airways (Healthy) Model
• Ex Vivo Tertiary or Lower Airways (Diseased) Model
• Ex Vivo Tertiary or Lower Airways (Bronchodilation) Model