3D Ex Vivo Human Brain Tissue Model Introduction

As a reputable innovative bio company, Creative Biolabs has over 10 years of experience in sourcing ethical human brain tissue samples and constructing ex vivo models. Our samples are processed using proprietary methods to maximize the success of experiments involving preclinical drug development.

Significance of Ex Vivo Models

The brain is the command center of the central nervous system (CNS), which is closely related to many intellectual activities of the body, such as processing, integrating, and coordinating information received from the sense organs. Dysfunction and disease in the brain can affect the entire body. Generally speaking, human brain diseases are divided into two categories, neurodegenerative diseases and neuropsychiatric diseases. Both can treat or suppress the symptoms of the disease with drugs, surgery, and physical therapy, but there is currently no cure for the disease. In recent years, the development of multiple experimental models has contributed to the progress of neuroscience, but each model has certain limitations.

Fig.1 Overview of commonly used model systems for studying the brain. (Lovett, 2020)

Why Choose Ex Vivo Human Brain Tissue Models?

Compared with traditional cell culture models and animal models, 3D culture has gradually emerged as a promising model to recapitulate the structure and function of the human brain.

Applications

Ex vivo brain cultures allow an overview of important features of the human brain in both health and disease, thereby providing a powerful tool to examine the pathophysiology of the disease. In addition, our obtained brain samples were snap-frozen and fixed with a formalin solution. These human tissue samples perform critical functions in several ways, such as bulk RNA extraction, proteomic and expression analysis, and immunocytochemistry. In addition, high-quality brain tissue samples are suitable for neuroscience research and preclinical drug discovery. Based on the above reasons, the 3D brain model may provide new ideas for the research on the pathogenesis of brain diseases and the development of effective drugs for diseases.

After decades of accumulation and expansion, Creative Biolabs has accumulated rich and constant experience in the field of 3D ex vivo human brain tissue models. We provide samples of normal and diseased human tissue. Importantly, demographic details such as gender, age and cause of death are also reported along with the sample. With abundant global medical resources, our proprietary human brain tissue model can provide a strong guarantee for your preclinical drug development. Please contact us in time to obtain a custom tissue model to meet your specific experimental needs.

More models can be obtained through the following links:

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