Barrier On-a-Chip Model Introduction

Creative Biolabs has developed in vitro barrier on-a-chip model which provides a dynamic physicochemical microenvironment for maintaining the barrier function of tissues. Our model provides you with a novel way to investigate these barriers in diseases, which might reveal new mechanisms and treatments.

Formation of Our Barrier on-a-chip Model

Our barrier on-a-chip model includes two polystyrene compartments and a central layer for tissue culture. The central layer is composed of polydimethylsiloxane (PDMS) and a thin layer of polymerase chain reaction (PCR) tape to seal a membrane or scaffold at the center. The basal compartment includes a fluidic channel and inlet/outlet channels for perfusion with culture media or flow-through of a receiver solution in an in vitro test. The apical compartment presents the same fluidic structure and can be used for perfusion of culture medium or ventilation. An exploded view of the chip model. The design includes integrated magnets to correctly seal the cell culture layer between the apical and basal compartments.

Fig 1. Design of the BoC with integrated electrodes for TEER measurements. (Zoio, 2021)

Advantages of Our Barrier on-a-chip Model

Applications of Our Barrier on-a-chip Model

Why Choose Us?

Creative Biolabs' advanced barrier on-a-chip model recapitulates complex biological barrier tissues, in both physiological and pathological states, and presents the potential to revolutionize pharmaceutical, toxicological and cosmetic applications. Our model serves as an experimental in vitro tool that can be used to quantify and characterize the barrier function of cells and tissues, which will contribute to your relevant study. View below for more barrier tissue-on-a-chip models.

• Blood-brain Barrier (BBB) on-a-chip Model
• Skin on-a-chip Model
• Gastrointestinal Tract (GI tract) on-a-chip Model
• Kidney Renal Proximal Tubule (RPT) on-a-chip Model
• Blood Vessel on-a-chip Model

Related Services

Supplementing our comprehensive range of barrier tissue-on-a-chip models, we present tailored 3D biology-based supporting assays designed to enhance your drug discovery initiatives. Our dedication extends to enriching your preclinical research journey, spanning both services and products. If you have specific preferences for our barrier tissue-on-a-chip models or desire to delve deeper into Creative Biolabs' 3D biology services, please feel free to contact us for in-depth discussions.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction