Blood-Brain Barrier (BBB) On-a-Chip Model Introduction

By using advanced microfluidic technology, nanofabrication, and integrated sensors, Creative Biolabs provides you with a new generation of in vitro engineered microphysiological blood-brain barrier (BBB) on-a-chip model, which is capable of mimicking the basic function of the BBB in vivo. Our BBB-on-a-chip model can be used in a wide range of applications, including central nervous system (CNS) disease models, high-throughput screening of new therapeutics, and neurotoxicity testing.

Construction of Blood-Brain Barrier-on-a-chip Model

Our technology has been applied to overcome the limitations of conventional BBB models, which include the lack of physiological relevance, the limited barrier integrity, the inconsistent expression of transporters and receptors, and the limited long-term stability. The scientists with rich experience at Creative Biolabs have advanced the design of BBB on-a-chip model. We use a porous membrane to separate chambers that one comprises endothelial cells (ECs) and the opposite side consists of astrocytes and pericytes. This approach results in improved functionalities of the BBB. Talk to our experts about your specific requirement.

Advantages of Our Blood-Brain Barrier-on-a-chip Model

Wide Applications

Our versatile BBB-on-a-chip Model supports a wide range of potential applications, such as toxicology studies, the development of novel therapeutics, drug screening, and fundamental brain research. This innovative technology is a promising alternative to reduce animal studies and provide opportunities for high-throughput or single-cell manipulation.

Fig 2. Applications and technical strengths of BBB-on-chip models. (Oddo, 2019)

Why Choose Us?

The development of Creative Biolabs' blood-brain barrier (BBB) on-a-chip model offers a physiologically relevant platform that can accurately recapitulate BBB phenotypes and enables monitoring of complex intercellular communications, which could advance your understanding of neurological diseases as well as the development of new therapies and help you discovering unprecedented insights into the functions of the BBB in health and disease. Visit our website for more barrier tissue-on-a-chip models.

• Skin on-a-chip Model
• Gastrointestinal Tract (GI tract) on-a-chip Model
• Kidney Renal Proximal Tubule (RPT) on-a-chip Model
• Blood Vessel on-a-chip Model
• Barrier on-a-chip Model

Related Services

With our expansive selection of barrier tissue-on-a-chip models, we introduce a suite of tailored 3D biology-based assays that are poised to amplify your preclinical research endeavors. Led by a team of proficient scientists in the field of 3D biology, we are enthusiastic about sharing detailed insights into our offerings, spanning services, and products alike. Whether you have specific requisites for our barrier tissue-on-a-chip models or an interest in exploring Creative Biolabs' comprehensive 3D biology services, please contact us for more information.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction