Blood Vessel On-a-Chip Model Introduction

The in vitro culture of tissues and vascular cells provides the basis for our understanding of other aspects, such as endothelial cell biology, cell-shape regulation, and the vessels' responses to physical forces. Creative Biolabs' blood vessel on-a-chip model links in vivo with in vitro research, which has overcome the major challenge in the field.

Formation of Blood Vessel on-a-chip Model

Using silicone molds together with casting gels made of collagen, Creative Biolabs has created microvessels that replicated some aspects of angiogenesis. The microvessels are beautifully lined with continuous endothelium and do not leak. Moreover, the vessels-when activated with appropriate biochemical signals-produced new branches in a process known as sprouting angiogenesis, and recruited pre-seeded mural cells, which normally associate with blood vessels and affect their functions.

Fig 1. In vitro microvessels. (Franco, 2012)

Advanced Blood Vessel On-a-chip Model at Creative Biolabs

Creative Biolabs' in vitro blood vessel on-a-chip model offers significant advantages in simulating the three-dimensional complexity, blood flow, cell-cell interactions, and proper extracellular environment found in living tissues. This innovative model provides an open and flexible assay where blood, plasma, or culture medium can flow through vessels that can be easily stimulated and manipulated. It enables real-time observation of endothelial cell behavior throughout various stages of angiogenesis. Moreover, this model not only allows researchers to shape the network according to their needs but also permits the dynamic reshaping and remodeling of the system by biological elements. With these capabilities, Creative Biolabs' blood vessel on-a-chip model offers a powerful tool for studying vascular biology and advancing our understanding of complex biological processes.

Applications of Blood Vessel on-a-chip Model

Why Choose Us?

The blood vessel on-a-chip model of Creative Biolabs mimics conditions in living blood vessels and is easy to assemble. Our model represents the establishment of a functional, hierarchically branched vascular network in vitro that could support the formation of new tissues from stem cells, which could pave the way for you to determine the micro-vessel elasticity as a prognostic factor of micro-vascular diseases. View below for more barrier tissue-on-a-chip models.

• Blood-brain Barrier (BBB) on-a-chip Model
• Skin on-a-chip Model
• Gastrointestinal Tract (GI tract) on-a-chip Model
• Kidney Renal Proximal Tubule (RPT) on-a-chip Model
• Barrier on-a-chip Model

Related Services

Creative Biolabs is a premier CRO company in the field of 3D Biology. We commit to offering a wide range of barrier tissue-on-a-chip models, coupled with our supporting services as shown below. If you have any interest in our models and services, please contact us for more information.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction