Skin-on-a-Chip Model Introduction

Creative Biolabs has been making efforts to develop our own commercially available skin-on-a-chip model. We have produced skin-on-a-chip model that incorporates a wide variety of cell types and structures that better resemble the real structure of the skin.

Construction of our Skin on-a-chip Model

The skin-on-a-chip model incorporates a fibrin-based dermal matrix to enhance the representation of human skin's structure and functions. The microfluidic device consists of five microstructured poly layers that are thermally bonded together, and the model facilitates the co-culture of human fibroblasts and keratinocytes.

Fig 1. Conceptual diagram of a full-thickness skin-on-a-chip model and schematic design of a chip device. (Zhang, 2018)

Advantages of Our Skin-on-a-chip Model

Proper vascularization allows an efficient nutrient and oxygen exchange, resulting in longer survival of the skin tissue.
Fulfill certain conditions such as mechanical properties, well-differentiated epidermis with stratum corneum, and dermis and epidermis properly linked through the basal lamina.
Able to better reproduce the tissue’s physiological environment.
Measure drug efficiency rapidly.
Allows the possibility of high-throughput platforms, where several conditions can be monitored at the same time under controlled parameters.

Applications of Skin-on-a-chip Model

Drug testing
Wound healing and tissue engineering.
In vitro applications for cosmetic products testing.
Skin diseases, skin irritation or allergies, and drug diffusion.
Skin graft applications

Why Choose Us

Combining with the latest advancements in tissue engineering, our model presents the opportunity for high throughput, automated, and realistic skin models for regenerative medicine, cosmetic, and pharmaceutical applications. Creative Biolabs’ skin-on-a-chip model has proven our merit in the development of miniaturized skin tissues on a chip such as portable, cost-effective, as well as powerful and very promising technology, and will assist you in the biomedical field of drug discovery and testing. View below for more barrier tissue-on-a-chip models.

Related Services

Creative Biolabs, a frontrunner in the global biotechnology landscape, consistently stays at the cutting edge of scientific innovation. Our commitment extends to providing an extensive array of reliable services, as below, catering to the diverse research requirements of our clients across the world. Contact us for more details.

Reference

Zhang, Q.; et al. Current advances in skin-on-a-chip models for drug testing. Microphysiol Syst. 2018, 2.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays