Kidney Renal Proximal Tubule On-a-Chip Model Introduction

Walking in the front section of biotechnology, Creative Biolabs demonstrates the need for better predictive models for nephrotoxicity for use in discovery and early development. Our three-dimensional in vitro Kidney Renal Proximal Tubule (RPT) on-a-chip has gained significant interest as a platform for nephrotoxicity in drug development, which will provide you a with generate predictive, animal free-system for the detection of nephrotoxicity.

Kidney Renal Proximal Tubule (RPT) on-a-chip Model at Creative Biolabs

In this innovative approach, the fishing line, which serves as a channel template, is encapsulated within a gelatin-fibrinogen solution that is cast into each chip. Once the matrix is enzymatically cross-linked, the fishing line is removed leaving behind open tubules that can be seeded with organoid-derived proximal tubule epithelial cells.

Fig 1. 3D OPTEC-on-a-chip model. (Aceves, 2022)

Our experienced scientists have developed a sophisticated process to generate the RPT on-a-chip model. The workflow below shows an overview of process used to create the RPT model. Talk to our expertise for more information.

Fig 2. Schematic overview of process used to create RPT on-a-chip model. (Creative Biolabs)

Advantages of Our Kidney Renal Proximal Tubule (RPT) on-a-chip Model

Applications

Why Choose Us?

The kidney renal proximal tubule (RPT) on-a-chip model of Creative Biolabs aims to enhance proximal tubule cultures towards their in vivo phenotype, and it is highly predictive and physiologically relevant in vitro proximal tubule model. Our kidney micro-physiological systems could be applied in the future to improve preclinical prediction of drug-induced kidney toxicity and eventually reduce kidney-related adverse effects of candidate drugs. View below for more barrier tissue-on-a-chip models.

• Blood-brain Barrier (BBB) on-a-chip Model
• Skin on-a-chip Model
• Gastrointestinal Tract (GI tract) on-a-chip Model
• Blood Vessel on-a-chip Model
• Barrier on-a-chip Model

Related Services

In combination with our diverse range of barrier tissue-on-a-chip models, we are excited to introduce tailored 3D biology-based assays, poised to elevate your preclinical research efforts. With a team of 3D biology experts, we are enthusiastic about sharing in-depth insights into our comprehensive suite of services and products. If you have specific needs for our barrier tissue-on-a-chip models and related services, please do not hesitate to contact us for more information.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction