3D Ex Vivo Human Acetylcholine-Carbachol Model Introduction

Creative Biolabs has the capability to deliver human 3D ex vivo human models for acetylcholine-carbachol-related research, including fresh-frozen unprocessed models, custom preservation protocols processed models, or difficult-to-obtain pathology samples.

Acetylcholine and Carbachol in Human

Acetylcholine is synthesized by cholinergic neurons and is responsible for transmitting signals across the neuromuscular junction. It binds to receptors on the surface of muscle cells, leading to contraction. In the brain, acetylcholine acts as a neurotransmitter and is involved in attention, learning, and memory. Carbachol, on the other hand, is a synthetic cholinergic agonist that mimics the action of acetylcholine by binding to the same receptors. It is used to treat glaucoma and to induce parasympathetic responses. These molecules have been studied extensively due to their involvement in several diseases such as Alzheimer's disease, Parkinson's disease, and glaucoma.

Fig 1. Acetylcholine-carbachol-related research in birds. (Jaffe, 2020)

Traditional Research Models

Despite the extensive research on acetylcholine and carbachol, the mechanism by which these molecules are involved in disease pathogenesis and how they act within a healthy body is not well understood. This is partly due to the lack of suitable research models that can mimic the complex interactions between these molecules and other biological systems.

Traditionally, animal models and cell culture models have been used to study the effects of acetylcholine and carbachol on various physiological processes. However, such models have several limitations, including ethical concerns, species-specific differences, and the inability to mimic the complex interactions between human tissues and biological systems.

Why Choose Ex Vivo Human Models?

Ex vivo models, which involve the use of fresh or processed human tissue samples, provide several advantages over traditional animal models.

Allow researchers to study the effects of acetylcholine and carbachol on human tissues.

Providing a more accurate representation of the biological processes involved in disease pathogenesis.

Ex vivo models allow for the testing of drugs and other treatments in a human-like environment, leading to more accurate results.

Reducing the need for animal testing, and avoiding the possibility of costly late failure.

What Can We Provide?

As a leading supplier of human tissue samples and a cutting-edge expert in biologically-related research, Creative Biolabs utilizes rigorous standards and professional techniques to provide the highest quality human biological specimens to scientists around the world. Through close collaboration with a network of hospitals and donation institutions across the globe, we collect each sample according to standard protocols to ensure compliance with strict ethical standards, alleviating any ethical dilemmas for you. We guarantee that each sample undergoes rigorous pathological examination and data collection to meet the unique requirements of various diseases or research projects. We have established extensive repositories to meet urgent demands and have the capability to provide customized human tissue in a manner that best fits the experimental design of our clients.

We have prepared a wide variety of ex vivo secondary airways-related tissue models,