3D Ex Vivo Human VIP-PACAP Model Introduction

Creative Biolabs has launched state-of-the-art 3D ex vivo human VIP-PACAP models to provide feasible solutions and expand infinite possibilities for your research project.

VIP-PACAP in Human

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) refer to a group of neuropeptides that play crucial roles in maintaining homeostasis in the human body. These neuropeptides are known to be involved in numerous physiological functions, including the regulation of circadian rhythms, neurotransmission, and immune response. In particular, they have been shown to exhibit potent anti-inflammatory and neuroprotective effects.

Fig 1. PACAP, VIP and their downstream effects. (Jansen, 2022)

Despite their potential therapeutic applications, the VIP and PACAP pathways remain poorly understood, and their dysregulation has been implicated in various diseases, including migraine, Alzheimer's disease, and inflammatory bowel disease. While a significant body of research has been conducted on VIP and PACAP, the underlying mechanisms of their effects on human physiology and disease pathogenesis remain largely unknown.

Fig 2. PACAP-VIP signaling pathways. (Langer, 2022)

Our Services

Creative Biolabs offers a comprehensive 3D ex vivo human VIP-PACAP model for studying VIP-PACAP signaling and related diseases. Our team of experts provides guidance throughout the research process and is available for professional support on experimental design and data analysis. Our procurement and supply network operates with strict ethical standards, and each sample is collected according to standard operating procedures to ensure the highest quality of human tissue samples. We provide customizable tissue models based on specific disease states, demographics, and other factors, ensuring researchers have access to relevant donor data. You are free to select or customize in our 3D ex vivo secondary airways (healthy) contractility model, which including but not limited to:

• 3D Ex Vivo Human Adrenoceptors-Isoprenaline Model
• 3D Ex Vivo Human Acetylcholine-Carbachol Model
• 3D Ex Vivo Human Histamine Model

Our expertise in tissue processing and modeling, combined with our procurement and supply network, makes us an ideal partner for researchers looking to advance the understanding of VIP-PACAP system diseases. Contact us today to learn more about our VIP-PACAP research solutions.

Related Sections:

• Ex Vivo Secondary Airways (Healthy) Contractility Model
• Ex Vivo Secondary Airways (Diseased) Contractility Model
• Ex Vivo Tertiary or Lower Airways (Healthy) Model
• Ex Vivo Tertiary or Lower Airways (Diseased) Model
• Ex Vivo Tertiary or Lower Airways (Bronchodilation) Model