3D Ex Vivo Human Intestine Tissue Model Introduction

The small intestine is a vital digestive organ with a complex ecosystem that is susceptible to pathogen infection. Many studies have focused on gut mechanisms, and as a result, more and more models, including cell culture models, animal models, ex vivo models, and organoids have been developed. At Creative Biolabs, our custom isolated human small intestine models provide a powerful platform for your intestine mechanisms research and preclinical drug development.

Limitations of Common Models

• The development of animal models requires sufficient space and many rearing facilities and materials.
• Animals are complete organisms in themselves, with complex networks and systems that maintain their homeostasis. Therefore, it is difficult to conduct relevant experiments immediately.
• There are limited methods of modifying the condition of animals, and reliance on dietary modification and compound injections to achieve specific animal models is a common strategy. But diet can influence the intestine.
• Using animal models to obtain results on human responses and physiology is costly and time-consuming.
• There are concerns about the welfare of laboratory animals, and the promotion of animal models does not match the trend of reducing the use of animals in research.

Features of 3D Ex Vivo Human Intestine Models

Many studies have identified some human-specific biological responses that cannot be mimicked in animal models. Therefore, ex vivo models are becoming an attractive tool. An ex vivo model is cultured outside an organism but contains functional living tissue with the complex cellular environment found in vivo. At Creative Biolabs, a wide variety of ex vivo models are available, especially intestinal models.

Fig.1 Overall scheme of experimental model. (Jung, 2022)

Our intestinal models have the following characteristics:

Fig.2 Characteristics of our models. (Creative Biolabs)

Applications of 3D Ex Vivo Human Tissue Model

Ex vivo intestinal tissue plays a crucial role in the prediction of intestinal injury repair. In addition, the model is closely linked to the validation of drug absorption, metabolism, and drug-induced toxicity.

Fig.3 Application of ex vivo models. (Creative Biolabs)

More 3D Ex Vivo Human Digestive System Tissue Models at Creative Biolabs

The diverse human ex vivo models provided by Creative Biolabs can deepen the understanding of the mechanism of intestinal disease development and facilitate the progress of preclinical drug development projects. Our professional team will provide customized solutions and suitable ex vivo models for your drug development project according to your unique needs. Please contact us in time to discuss your project for reasonable advice and professional help.

More models are available through the following links:

• 3D Ex Vivo Human IBD Permeability Model
• 3D Ex Vivo Human IBD Anti-inflammatory Model
• 3D Ex Vivo Human Healthy GI Permeability Model
• 3D Ex Vivo Human Healthy GI ion-channel Model
• 3D Ex Vivo Human Healthy Gastrointestinal Metabolism Model
• 3D Ex Vivo Human Colon Tissue Model

Related Sections:

• Ex Vivo Human Genitourinary Tissue Model
• Ex Vivo Human Skin System Tissue Model
• Ex Vivo Human Urinary System Tissue Model
• Ex Vivo Neurological System Model
• Ex Vivo Human Digestive System Model
• Ex Vivo Human Musculoskeletal System Tissue Model
• Ex Vivo Human Respiratory System Tissue Model
• Ex Vivo Human Endocrine System Tissue Model
• Ex Vivo Human Cardiovascular Tissue Model