3D Ex Vivo Human Healthy Gastrointestinal Metabolism Model Introduction

Equipped with world-leading technology platforms and professional scientific staff, Creative Biolabs is proud to offer the most qualified products and the best service in the field of 3D ex vivo human tissue models development. Here, we describe the novel 3D ex vivo human healthy gastrointestinal metabolism model for our clients all over the world.

Description of Gastrointestinal Cancer and Models

In recent decades, a large amount of knowledge has been generated in the field of gastrointestinal cancer. Recent discoveries in the field of cancer metabolism provide new insights into cancer treatment. In addition, studies have demonstrated metabolic reprogramming in the tumor microenvironment implying the need for sophisticated models in cancer research. Tumor xenografts derived from patients and 2D cell lines are classical models. The development of organoid technology has further promoted the development of 3D models to provide more important parameters in the study of cancer metabolism.

The organization of the colon crypt and the transition to carcinoma.Fig.1 The organization of the colon crypt and the transition to carcinoma. (Silva-Almeida, et al., 2020)

The Necessity of 3D Model Development

The 3D model provides additional support for metabolic research and personalized medicine.

  • Avoids many of the limitations of 2D models, such as inability to properly model and study colorectal cancer.
  • The 3D model contains multiple cell types and cell populations, thereby capturing several important parameters.

Services at Creative Biolabs

After years of hard work, we have established a formal and efficient source of human biological tissue samples. Under the premise of complying with relevant regulations, standard and customized 3D ex vivo human healthy gastrointestinal metabolism models can be delivered as soon as possible to ensure that your project experiments can be carried out quickly.

Available Models at Creative Biolabs

3D Ex Vivo Human IBD Permeability Model

3D Ex Vivo Human IBD Anti-inflammatory Model

3D Ex Vivo Human Healthy GI Permeability Model

3D Ex Vivo Human Healthy GI ion-channel Model

3D Ex Vivo Human Colon Tissue Model

Based on our advanced platforms and extensive experience, Creative Biolabs can not only provide super high-quality data, but also help you establish the novel research pipeline and create new techniques for your own projects. Our service can be tailor-designed to meet your specific needs. If you are interested in our products and services, please do not hesitate to contact us for more details.

Reference

  1. Silva-Almeida, C.; et al. 3D gastrointestinal models and organoids to study metabolism in human colon cancer[C]//Seminars in Cell & Developmental Biology. Academic Press. 2020, 98: 98-104.
Research Model

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