3D Ex Vivo Human Healthy GI Ion-channel Model Introduction

In the field of human gastrointestinal disease development, Creative Biolabs has many years of experience and can provide various forms of services. Our newly developed 3D ex vivo human healthy GI ion-channel model allows customers to conduct comprehensive testing and verification of the effectiveness and safety of their drugs.

Functions of GI Ion-channel in GI Disorders

The gastrointestinal tract (GIT) plays important roles in multiple human physiological functions and mechanisms, including food digestion, nutrient uptake, drug absorption, electrolyte transport, etc.

Studies have shown that mechanosensation is essential for normal physiological functions of the GIT, and abnormalities in mechanosensation result in a variety of GI disorders, especially irritable bowel syndrome (IBS) and GI tumors.

Ion channels associated with mechanosensitivity mainly include transient receptor potential (TRP) channels, voltage-gated ion channels, two-pore domain potassium (K2p) channels, large-conductance Ca²⁺-activated K⁺ (BKCa) channels. Therefore, mechanosensitive ion channels may provide new directions and ideas for the treatment of gastrointestinal diseases. Since experimental animals cannot well mimic human physiology and yield reliable predictive data. Novel in vitro 3D human intestinal tissue models need to be developed to predict the safety and efficacy of drugs and toxicants during drug development.

Fig.1 Expression of the mechanosensitive ion channels in the gastrointestinal (GI) tract. (Yang, et al., 2022)

Services at Creative Biolabs

In GI tumors, mechanosensitive ion channels promote malignant progression of tumors. In IBS, visceral hypersensitivity (VH) is an important biomarker and closely related to plasma channels of Piezo, TRPV4, TRPA1 and Nav channel. Through multiple channels, we can obtain the highest quality human biological tissue samples while ensuring the confidentiality and safety of patients and donors. Subsequently, according to the special needs of customers, we can provide a variety of customized 3D ex vivo models.

Available Models at Creative Biolabs

3D Ex Vivo Human IBD Permeability Model

3D Ex Vivo Human IBD Anti-inflammatory Model

3D Ex Vivo Human Healthy GI ion-channel Model

3D Ex Vivo Human Healthy Gastrointestinal Metabolism Model

3D Ex Vivo Human Colon Tissue Model

As one of the well-recognized experts in the field of human 3D ex vivo models development, Creative Biolabs is confident in offering the high-quality products and comprehensive services for our clients all over the world. Based on our extensive experience and advanced technologies, we can take on the most challenging projects. If you are interested in our products and services, please do not hesitate to contact us for more details.

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