3D Ex Vivo Human Colon Tissue Model Introduction

Creative Biolabs has long-term devoted to the development and application of 3D ex vivo human models for cancer research and drug discovery. Depending on novel technologies and tools, now we can provide the 3D ex vivo human colon tissue models to meet the specific need of each customer with the best project design.

The Ex Vivo Human Colon Tissue

The human colon contains typical histological structures such as mucosa, submucosa, muscularis, as well as serosa/adventitia. In normal human physiological functions, the colon is primarily responsible for the temporary storage and transport of feces. Human organ culture technology enables the research of physiology and pathophysiology at the whole tissue level. Past studies have shown that normal human colon tissue can be preserved ex vivo for several days or longer and thus can be used for the study of colon tissue-related diseases. More critically, the histological and immunohistological features of normal and neoplastic colon tissues were preserved during organ culture. For example, signaling events that occur under elevated Ca²⁺ concentrations can be elucidated using intact ex vivo colon tissue models.

Fig.1 Histological features of neoplastic colon tissue in organ culture. (Dame, et al., 2010)

Services at Creative Biolabs

Derived from stem cells, organoids are self-organized 3D tissues to highly simulate the official. The human intestinal organoids contain the lumen and surrounding enterocytes that have been served as ex vivo models for research. Customized products and services can also meet the special needs of customers. Compared with 2D models, our 3D ex vivo human colon tissue models can better mimic the structure and function of human colon tissue for basic research and drug testing. What's more, new drugs and even new therapies can be further developed by using patient-derived tissues.

Available Models at Creative Biolabs

3D Ex Vivo Human IBD Permeability Model

3D Ex Vivo Human IBD Anti-inflammatory Model

3D Ex Vivo Human Healthy GI Permeability Model

3D Ex Vivo Human Healthy GI ion-channel Model

3D Ex Vivo Human Healthy Gastrointestinal Metabolism Model

Creative Biolabs is one of the well-recognized experts who are professional in applying advanced human models for a broad range of project objectives. As a pioneer and the undisputed global leader in drug discovery, we have the capability to enable you to free up your time for core work and project. If you are interested in our products and services, please do not hesitate to contact us for more details.

Related Sections:

• Ex Vivo Bile Duct Model
• Ex Vivo Esophagus Model
• Ex Vivo Gallbladder Model
• Ex Vivo Larynx Model
• Ex Vivo Pharynx Model
• Ex Vivo Palate Model
• Ex Vivo Liver Model
• Ex Vivo Pancreas Model
• Ex Vivo Parotid Gland Model
• Ex Vivo Salivary Gland Model
• Ex Vivo Stomach Model
• Ex Vivo Intestine Model