3D Ex Vivo Human IBD Anti-inflammatory Model Introduction

The small intestine is an important organ of the digestive system that presents important roles in food digestion and maintaining homeostasis. The gut is a complex ecosystem containing a large number of microorganisms that are closely related to human health and pathogenesis. In recent years, the interaction of the microbial community with the host immune system has been extensively studied to develop immune or microbial therapies. Here, Creative Biolabs provides the novel 3D Ex Vivo human IBD anti-inflammatory model for your research.

Ex Vivo Human IBD Anti-inflammatory Model

In humans, inflammatory Bowel Disease (IBD) is a complex systemic disorder of the gastrointestinal tract leading to tissue damage and even the development of cancer. Therefore, the development of suitable models is crucial to advance research and develop treatments.

Advances in stem cell technology and 3D biomaterial technology have enabled stem cell-derived intestinal samples from human patients to be used for ex vivo model development. For example, the obtained inflamed colon tissue from IBD patients can be subdivided into small pieces and then submerge in a special medium. Recently, there is also a novel ex vivo microfluidic device (Gut-Ex-Vivo System, GEVS) developed for IBD research. Overall, the classical ex vivo models include using chamber, everted gut sac, and microfluidic gut-on-chip.

Fig.1 Major intestinal models and their designs. (Jung& Kim, 2022)

Advantages of the Ex Vivo ModelM

Available Models at Creative Biolabs

3D Ex Vivo Human IBD Permeability Model

3D Ex Vivo Human Healthy GI Permeability Model

3D Ex Vivo Human Healthy GI ion-channel Model

3D Ex Vivo Human Healthy Gastrointestinal Metabolism Model

3D Ex Vivo Human Colon Tissue Model

To better understand the pathophysiology and etiology of IBD, a variety of in vitro, in vivo animal models, and ex vivo models have been designed. In fact, each has its own set of advantages and disadvantages, and multiple models are recommended for simultaneous IBD research. For customers' special project needs, we can provide customized service solutions. If you are interested in our products and services, please do not hesitate to contact us for more details.

Related Sections:

• Ex Vivo Bile Duct Model
• Ex Vivo Esophagus Model
• Ex Vivo Gallbladder Model
• Ex Vivo Larynx Model
• Ex Vivo Pharynx Model
• Ex Vivo Palate Model
• Ex Vivo Liver Model
• Ex Vivo Pancreas Model
• Ex Vivo Parotid Gland Model
• Ex Vivo Salivary Gland Model
• Ex Vivo Stomach Model
• Ex Vivo Intestine Model