3D Ex Vivo Human Kidney Adenocarcinoma Model Introduction

3D ex vivo disease model technology has gained importance as an emerging in vitro culture technology. This 3D organ-type system can be derived from cell lines, primary tissues, embryonic stem cells, induced pluripotent stem cells, and organ explants composed of multiple tissue types with the ability to self-renew and self-organize. Creative Biolabs can provide 3D ex vivo human kidney adenocarcinoma model and related service to support the simulation of similar pathological kidney tissues.

Conventional 2D Ex Vivo Culture and Emerging 3D Ex Vivo Models

Conventional 2D ex vivo culture

Not suitable for high throughput screening.
Not suitable for genetic research operations.
Obstruction in cancer-targeted therapy.

Emerging 3D ex vivo models

Simulating the structural relationship between tumor cells and mesenchyme.
Simulation of developmental processes and renal function of in situ tissues and organs.
Suitable for therapeutic screening to achieve precision medicine.

Applications

Why choose us?

Preservation of the original gene expression pattern and epigenetic composition of the tissue.
3D culture conditions efficiently replicate molecular and histological phenotypes of renal disease in vivo and provide pathogenesis-related mutational information.
Cell clusters exhibit a pattern similar to that of primitive cell colonies Main features of the model for maintaining cell morphology in culture (abundant lipids, clear cytoplasm, and diverse communities).
Continuous optimization of model building solutions to simplify the production process and improve reliability and reproducibility.

Fig. 1 Characterization of 3D ex vivo renal disease models. (Grassi, 2019)

Creative Biolabs Supports Multiple Kidney Tissue Models

Kidney adenocarcinoma is a heterogeneous kidney cancer that differs in disease biology, clinical behavior, prognosis, and response to systemic therapy. Creative Biolabs offers 3D ex vivo human kidney adenocarcinoma model with the advantage of maintaining the original tissue genotype and biological properties for higher translatability and predictability in the development of drug candidate applications. Please contact us to discuss how we can assist your projects.

Reference

Grassi, L.; et al. Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases. Cell Death Dis. 2019, 10(3): 201.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays