3D Ex Vivo Human Kidney Nephroblastoma Model Introduction

Creative Biolabs has a well-established and growing library of 3D ex vivo human kidney tissue samples to develop 3D ex vivo human kidney nephroblastoma models for disease research and drug development applications.

Construction of 3D Ex Vivo Human Kidney Nephroblastoma Model

Since tumor cells have different growth characteristics and biological behaviors from normal kidney cells, establishing 3D culture models with characteristics of kidney nephroblastoma has become a powerful tool to study aspects of kidney disease progression and drug resistance mechanisms.

3D ex vivo Nephroblastoma Model

Case 1: Cell-matrix co-culture model.
Nephroblastoma cells are inoculated in vitro in a stroma containing endothelial cells, fibroblasts, smooth muscle cells, and smooth muscle epithelial cells, which are passaged and differentiated to form the same 3D structure as nephroblastoma cells.
This model was mainly used to observe Nephroblastoma tissues and the vascular and lymphatic structures in them. By electron microscopic observation of this model, Nephroblastoma cells can be seen to be distinctly different from normal kidney tissues.

Multidirectional 3D Nephroblastoma Model

Case 2: matrix-scaffold-cell 3D co-culture model.
In vitro inoculation of nephroblastoma cells on media containing different proportions of stroma or scaffold materials, after passaging and differentiation to form a 3D structure similar to that of kidney tumor tissue.

Fig. 1 Applications of 3D kidney organ model. (Gupta, 2021)

Advantages of 3D Ex Vivo Human Kidney Nephroblastoma Model

Advantages

More 3D Ex Vivo Human Kidney Tissue Models at Creative Biolabs

Creative Biolabs has successfully applied 3D ex vivo culture technology to create preclinical kidney tissue models, providing solutions for basic research in the biology of multiple kidney diseases. These models can be used to evaluate drug candidates and personalized therapies.

Our Leading Services

Suitable for customizing and preparing models according to specified requirements, such as fixing and freezing methods, etc.
As a source of material for various histological and biochemical analyses related to nephroblastoma.
The highest possible level of quality assurance to improve the integrity of the model product and to reflect realistic physiological functions.

Creative Biolabs offers optimized 3D ex vivo human kidney nephroblastoma models that can serve as the basis for successful preclinical drug development and potential clinical translation. We are equipped with industry-leading technical systems and shipping networks to ensure high-quality delivery to our customers. Please contact us to accelerate the success of your project.

Reference

Gupta, N.; et al. 3D kidney organoids for bench-to-bedside translation. J Mol Med (Berl). 2021, 99(4): 477-487.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

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