3D Ex Vivo Human Kidney Tissue Model Introduction

Ex vivo tissue modeling has become an important tool for medical research, and the development and widespread use of 3D biotechnology has met the increased demand for in vitro kidney tissue models. Creative Biolabs offers a variety of services related to 3D ex vivo kidney tissue models to support their application in the fields of regenerative medicine and tissue engineering.

Traditional 3D Technology and 3D Biotechnology

Traditional 3D model		3D Biotechnology
Tissues and cells are limited by many factors such as extracellular matrix structure, spatial structure, and mechanical properties, which make it difficult to be designed and constructed into ideal artificial tissues.		Cell-based and scaffold materials are the main means. In particular, the stem cell 3D printing technology constructs and cultures stem cells in 3D to form pluripotent stem cells.
Scaffold materials of different sizes and densities are usually used for cell culture with appropriate physical properties optimization. The process is complex and cumbersome, and the poor cell culture results limit the clinical application of tissue engineering.		The unique self-renewal and multidirectional differentiation potential of stem cells is utilized to achieve functional reconstruction of tissues and organs.
The materials used in vivo organ models are often a single type or multiple types of cells or tissues and therefore do not fully reflect the organs and functions required for the study.		Stem cell-based biomodelling technology can be used to form new normal cells or tissues and organs not only by somatic cells undergoing re-differentiation, but also by obtaining a specific functional phenotype.

Features and Benefits of 3D Ex Vivo Human Kidney Tissue Model

Directed differentiation of the kidney

Supporting biological imaging and histological analysis.
Showing abundant features of tubular epithelial cells and renal interstitial cells, also containing some mitotic cells and mast cells.

Directed differentiation of the kidney

Traditional renal histology studies: Performed in vitro, with limitations in gaining insight into its structure and function.
3D ex vivo kidney tissue model: It is feasible and effective in simulating real human kidney function and pathological responses.

Directed differentiation of the kidney

3D ex vivo kidney tissue models have been used to study many kidney-related diseases, such as glomerulonephritis, nephrotic syndrome, polycystic kidney, and glomerulosclerosis.
It helps to understand the anatomical structure of the kidney and its physiological function, which is important for the diagnosis and treatment of kidney diseases.

Fig. 1 Directed differentiation of the kidney in vitro. (Tekguc, 2022)

Multiple 3D Ex Vivo Human Kidney Tissue Models at Creative Biolabs

In addition, our platform supports a variety of services related to 3D ex vivo human urinary tissue models.

Over the past few years, there has been a gradual increase in interest in renal histology. Creative Biolabs offers 3D biotechnology-based 3D ex vivo kidney tissue modeling services that support the provision of effective tools for kidney disease. Please contact us to learn more.

Reference

Tekguc, M.; et al. Kidney organoids: a pioneering model for kidney diseases. Transl Res. 2022, 250: 1-17.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

3D Ex Vivo Human Kidney Tissue Model Introduction

Traditional 3D Technology and 3D Biotechnology

Features and Benefits of 3D Ex Vivo Human Kidney Tissue Model

Multiple 3D Ex Vivo Human Kidney Tissue Models at Creative Biolabs

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