3D Ex Vivo Human Kidney Renal Cell Carcinoma Model Introduction

Improving the predictability of preclinical anti-cancer drug development through the 3D ex vivo model has been examined. Creative Biolabs continues to focus on how to accurately model the complex in vivo environment of kidney renal cell carcinoma, and provides services related to the 3D ex vivo human kidney renal cell carcinoma model in improving the diagnosis and new drug discovery process of kidney cancer.

Introduction to Kidney Renal Cell Carcinoma

Origins

Preservation of the renal unit or radical resection.

Histopathological types

The most common type is clear cell renal cell carcinoma, followed by papillary renal cell carcinoma and chromophobe renal cell carcinoma, as well as the rare collecting duct carcinoma.

Treatment approaches

Renal tubular epithelium that plays a role in reabsorption and urination.

Advantages of 3D Ex Vivo Human Kidney Renal Cell Carcinoma Model

The 3D ex vivo human kidney renal cell carcinoma model is an in vitro, artificially created, and cultured kidney organ with renal cell carcinoma that mimics its pathological changes. It is an essential tool for studying kidney regeneration, kidney renal cell carcinoma intervention, and tissue engineering with significant advantages.
Select cells and tissues of specific cell types or functions that break through the limitations of the research purpose.
Cells and tissues in the model can undergo regulatory processes such as differentiation, proliferation, and apoptosis in different ways, which can better study the mutual regulatory processes of cells and tissues.
Simulating multiple different human kidney renal cell carcinoma and functions is advantageous in studying multiple human kidney renal cell carcinoma.
Compared to in vivo organ models, the 3D ex vivo human kidney renal cell carcinoma model is closer to the human organ system in terms of cell number, degree of differentiation, and functional status.

Fig. 1 Efficient construction of patient-derived 3D renal cell carcinoma models. (Li, 2022)

Applications

Interpretation of signaling molecular and mechanistic changes in the development and maintenance of renal cell carcinoma and establishment of molecular features of the cancer phenotype.
Discovery of cancer cell origin biomarkers for various kidney renal cell carcinoma spectrums.
Development of preclinical drug screening systems and elaboration of specific interventions.

More 3D Ex Vivo Human Kidney Tissue Models at Creative Biolabs

Creative Biolabs provides comprehensive services related to 3D ex vivo human kidney renal cell carcinoma models. It not only facilitates the histological classification of kidney tumors and the identification of significant histopathological and immunohistochemical staining features, but also improves the understanding of kidney renal cell carcinoma and advances the treatment tools. Please feel free to contact us to discuss the details about how we can assist your projects.

Reference

Li, Z.; et al. Patient-derived renal cell carcinoma organoids for personalized cancer therapy. Clin Transl Med. 2022,12(7): e970.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

Related Sections:

Research Model

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