3D Ex Vivo Human Aorta Tissue Model Introduction

Creative Biolabs proudly launches 3D ex vivo human aorta tissue model, a crucial tool in studying cardiovascular disease and developing new drugs for this condition. With professional scientific team and advanced technology, we are committed to promoting global researchers' projects.

Introduction of Aorta

The aorta is the largest artery in the human body, responsible for carrying oxygen-rich blood from the heart to the rest of the body. The aorta is composed of three distinct layers, including the intima, media, and adventitia, each with a specific function. Several cardiovascular diseases, such as aortic aneurysms, aortic dissections, and atherosclerosis, may affect the aorta tissue. These diseases can result in the weakening or thickening of the artery walls, leading to an increased risk of heart attacks and strokes. Therefore, studying the pathogenic mechanism of these diseases and developing effective treatments is critical for improving patient outcomes.

Anterior segment of human aorta sample.Fig 1. Anterior segment of human aorta sample. (Brecs, 2019)

Traditional Models in The Study of Aorta Tissue

Traditional models used in the study of aorta tissue include animal models and in vitro cell cultures. While these models have their advantages, they also have significant limitations. Animal models may not accurately represent human disease, and in vitro cell cultures lack the complexity of in vivo tissue. The huge flaws of these models often lead to the failure of the previous research results to be successfully translated into successful and usable clinical results.

3D Ex Vivo Human Aorta Tissue Model

As the best research tool in the preclinical validation stage, our 3D ex vivo human aorta tissue model provides irreplaceable advantages, including its ability to accurately replicate in vivo conditions, its complexity and physiological relevance, and the availability of tissue from multiple donors. The model can be used to study the pathophysiology of atherosclerosis, evaluate the efficacy of new drugs and treatment options, and test the safety of medical devices.

3D Ex Vivo Human Aorta Tissue Model

Looking for More Models?

In response to the needs of cardiovascular disease research, we have established a comprehensive of 3D ex vivo human cardiovascular tissue models. To learn more details about these models, please click the links below.

Our Services

At Creative Biolabs, we are dedicated to providing researchers worldwide with high-quality 3D ex vivo human aorta tissue model. Our models have undergone a comprehensive review to guarantee their quality and reliability. We welcome the opportunity to discuss your projects and provide you with the best possible solutions and resources. Contact us today to learn more about our 3D ex vivo human tissue model and how it can advance your research.

References

  1. Brecs, I.; et al. Biomechanical properties of human dilated ascending aorta. Proceedings of The Latvian Academy of Sciences. 2019, 2(719): 107-111.
  2. Cesarini, V.; et al. Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms. Nature. 2019, 9: 12206.
  3. Kostina, D.; et al. Aortic graft at coronary artery bypass surgery as a source of human aortic smooth muscle cells. Cell Transplantation. 2017, 26(10): 1663-1668.
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