3D Ex Vivo Human Ischemic Arteries Model Introduction

Creative Biolabs proudly launches a powerful tool for studying the pathogenic mechanisms of ischemic arteries-related diseases. We provide a reliable and ethical supply of high-quality models for researchers to accelerate their heart failure research and drug development process.

Ischemic Arteries

The human circulatory system consists of arteries, veins, and capillaries that transport blood throughout the body. The ischemic arteries are a type of artery that is prone to occlusion or blockage due to the buildup of plaque or clots, leading to restricted blood flow, oxygen and nutrient deprivation, and ultimately tissue damage. To better understand the pathogenesis of ischemic arteries-related diseases and develop effective treatments, researchers need reliable and accurate models to mimic the complex biological environment of the human circulatory system.

Brain artery connectivity map of different species.Fig 1. Brain artery connectivity map of different species. (Sommer, 2017)

Traditional Models and Their Limitations

Research has been ongoing for many years, but the complexity of the circulatory system poses significant challenges. There are currently several traditional models used in the study of ischemic heart disease, including animal models and cell cultures. However, animal models cannot precisely replicate the pathological mechanisms underlying human ischemic arteries-related diseases with ethical considerations limiting the ability to perform certain experiments. Additionally, cell cultures provide a simpler environment to study the molecular mechanisms of ischemic arteries-related diseases, but they cannot replicate the complex cell-to-cell interactions and physiological environment of the human circulatory system.

Advantages of 3D Ex Vivo Human Ischemic Arteries Model

The 3D ex vivo human ischemic arteries model is a promising solution that can provide a realistic and personalized simulation of the human circulatory system's ischemic arteries with several advantages over traditional models.

3D Ex Vivo Human Ischemic Arteries Model

Looking for More Models?

To address the demands of cardiovascular disease research, we have successfully developed a series of ex vivo human tissue models listed below.

Our Services

As a leading company in preclinical drug discovery, Creative Biolabs offers researchers an exceptional and all-inclusive 3D ex vivo human ischemic arteries model to promote their projects. Our team of experienced professionals delivers guidance and expert support throughout the research process, including experimental design and data analysis. Please feel free to contact us for more detailed information.

References

  1. Sommer, C.J.; et al. Ischemic stroke: experimental models and reality. Acta Neuropathol. 2017, 133: 245-261.
  2. Clark, T.A.; et al. Artery-targeted photothrombosis widens the vascular penumbra, instigates peri-infarct neovascularization and models forelimb impairment. Nature. 2019, 9: 2323.
Research Model

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