3D Ex Vivo Human Atrial Fibrillation Model Introduction

Creative Biolabs has developed 3D ex vivo human atrial fibrillation model to promote global researchers' projects in the field of cardiovascular.

Atrial Fibrillation

Atrial Fibrillation (AF) is a prevalent cardiac arrhythmia that affects millions of people worldwide. AF is a complex condition with multifactorial etiology. It is characterized by rapid and irregular electrical impulses that cause the atria to quiver instead of contracting properly. This, in turn, leads to blood pooling and increases the risk of clot formation and stroke. The pathophysiology of AF is still not fully understood, and this makes it challenging to develop effective therapeutic interventions.

Fig 1. Atrial fibrosis in endocardium and myocardium. (Choi, 2016)

3D Ex Vivo Human Atrial Fibrillation Model

Traditional AF models, such as animal models, have limitations due to differences in anatomy and physiology compared to humans. This can hinder the translation of research findings to human patients. In vitro models also have limitations, such as the inability to accurately mimic the complex microenvironment of the heart.

3D ex vivo human atrial fibrillation model is collected from human donations, and it faithfully reproduces the anatomical and physiological features of the human atria, including fibrosis, scar formation, and electrical heterogeneity. It provides a more accurate representation of human disease compared to animal and in vitro models. Human tissue model enables the evaluation of individual differences in disease severity and drug response, which is essential for personalized medicine. Our model also allows for the testing of antiarrhythmic drugs and other therapies under conditions that mimic the human atrial environment, which enhances the likelihood of successful clinical translation.

What Can Be Done?

Cases have illustrated the usefulness of our 3D ex vivo human atrial fibrillation model in research and drug development.

• Antiarrhythmic drug efficiency evaluation
• Cardiotoxicity tests
• AF pathogenesis investigation
• Potential therapeutic targets identification
• Inflammation research
• …

Fig 2. Human atrial tissue. (Ly, 2022)

Looking for More Models?

With professional scientific team and advanced technology platform, we have successfully developed a full package of 3D ex vivo human cardiovascular tissue models listed below to promote worldwide researchers' project in the field of cardiovascular.

• 3D Ex Vivo Human Heart Failure Model
• 3D Ex Vivo Human Arrhythmogenic Disorders Model
• 3D Ex Vivo Human Vasoconstriction Model
• 3D Ex Vivo Human Cardiac Contractility Model
• 3D Ex Vivo Human Vasodilation Model
• 3D Ex Vivo Human Ischemic Arteries Model
• 3D Ex Vivo Human Coronary Arteries Model
• 3D Ex Vivo Human Chorionic Plate Arteries Model
• 3D Ex Vivo Human Saphenous Veins Model
• 3D Ex Vivo Human Aorta Tissue Model
• 3D Ex Vivo Human Artery Tissue Model

Our Services

Creative Biolabs is committed to assisting global customers' research with our reliable and ethical supply of 3D ex vivo human AF models. We ensure that every sample used for these models was obtained under strict ethics requirement. Please feel free to contact us for more details about how we can promote your project.

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