3D Ex Vivo Human Heart Failure Model Introduction

Creative Biolabs is dedicated to providing the best 3D ex vivo human heart failure model. This model has revolutionized the study of heart failure, providing researchers with a reliable and ethical tool to better understand this complex condition.

Heart Failure

The heart is a complex organ responsible for pumping blood throughout the body. It consists of four chambers, with two atria and two ventricles, and is supported by a network of blood vessels, valves, and electrical pathways. Heart failure is a condition where the heart is unable to pump blood effectively, leading to a range of symptoms and complications. There are several types of heart failure, including systolic, diastolic, and heart failure with preserved ejection fraction (HFpEF). These different types have distinct underlying molecular mechanisms, such as impaired contractility, stiffness, or abnormalities in the regulation of calcium signaling.

Fig 1. Heart failure cardiac tissue model. (Yoon, 2013)

3D Ex Vivo Human Heart Failure Model

Traditionally, heart failure is studied using animal models, such as rodents or larger mammals. While these models have provided valuable insights into heart failure pathophysiology, they also have limitations, such as differences in anatomy and physiology between animals and humans. Additionally, some treatments that are effective in animals have not translated to humans.

To overcome these limitations, Creative Biolabs has turned to 3D ex vivo human heart failure models, which are derived from human heart tissue obtained from donors. These models provide a more accurate representation of human heart physiology and pathology, allowing for more effective drug discovery and disease modeling. They can also be used to test the safety and efficacy of new treatments before they are tested in humans, reducing the risk of adverse events.

What Can Be Done?

Research has demonstrated the potential of the 3D ex vivo human heart failure model to advance heart failure research, which including but not limited to:

• Mechanism study
• Cardiotoxicity tests
• Compound screening
• Novel drug evaluation
• Heart failure progress research
• …

Looking for Other Models?

With years of experience and advanced platform, we have developed a series of 3D ex vivo human cardiovascular tissue models to promote the development of global customers' projects.

• 3D Ex Vivo Human Atrial Fibrillation Model
• 3D Ex Vivo Human Arrhythmogenic Disorders Model
• 3D Ex Vivo Human Vasoconstriction Model
• 3D Ex Vivo Human Cardiac Contractility Model
• 3D Ex Vivo Human Vasodilation Model
• 3D Ex Vivo Human Ischemic Arteries Model
• 3D Ex Vivo Human Coronary Arteries Model
• 3D Ex Vivo Human Chorionic Plate Arteries Model
• 3D Ex Vivo Human Saphenous Veins Model
• 3D Ex Vivo Human Aorta Tissue Model
• 3D Ex Vivo Human Artery Tissue Model

Our Services

Creative Biolabs provide a reliable 3D ex vivo human heart failure model for global researchers. Its accuracy, physiological relevance, and ethical availability make it a valuable tool for the development of new therapies and a better understanding of this complex condition. We ensure each sample undergoes a rigorous, comprehensive review to ensure ethical availability and compliance with regulatory standards. Our inquiry-supply process is professional and efficient, and we are always available to assist our clients with any questions or concerns they may have. Contact us now for expert assistance on how we can assist your research.

Related Sections:

• Ex Vivo Human Genitourinary Tissue Model
• Ex Vivo Human Skin System Tissue Model
• Ex Vivo Human Urinary System Tissue Model
• Ex Vivo Neurological System Model
• Ex Vivo Human Digestive System Model
• Ex Vivo Human Musculoskeletal System Tissue Model
• Ex Vivo Human Respiratory System Tissue Model
• Ex Vivo Human Endocrine System Tissue Model
• Ex Vivo Human Cardiovascular Tissue Model