3D Ex Vivo Human Bile Duct Tissue Model Introduction

Creative Biolabs provides human 3D bile duct tissue models according to approved protocols, we have the ability to customize every order according to your exact needs, making the rare samples in the past now at your fingertips.

Bile Duct and Digestive System Disease

The bile duct is a tubular organ that connects the liver, gallbladder, and small intestine, and functions as the main transport channel for bile. Bile collected from the lobules of the liver is transported to the gallbladder and stored until feeding. Anatomically, the bile duct mucosa is composed of a single layer of columnar epithelial cells, under which there are relatively solid layers of elastic fibers and collagen fibers. Biliary ulcers, chronic inflammation, choleliths, and congenital bile duct dilatation may all cause structural damage to the bile duct wall, cholestasis, or other pathological damage. Bile duct disease also accounts for about one-third of liver transplants. Research and development of interventions of such illnesses are inseparable from research models with good physiological characteristics.

Fig 1. Anatomical diagram of the liver. (Lendahl, 2021)

Why Choose 3D Ex Vivo Human Bile Duct Tissue Model?

Traditional two-dimensional cell culture models have great limitations in dealing with intra-organ disorders with functional structures, and tissue engineering models have become novel tools for bile duct research. In vitro constructed bile duct tissue modeled by CAD combined with cells, materials, and various bio-stimulatory signals may provide a viable alternative for the management of common bile duct disease. However, the construction of such models often requires a large amount of specific and characteristic knowledge of anatomy and physiology, which greatly limits the development of effective bile duct pathological models. In addition, commonly used biomedical devices such as biliary stents cannot be tested in vivo in small animal models due to anatomical constraints, and testing in large animal models will result in high costs, stringent approval processes, and ethical issues.

Fig 2. Morphological characteristics of cells in the lumen of the bile duct. (Liedekerke, 2022)

More Ex Vivo Human Digestive System Tissue Model at Creative Biolabs

Today, Creative Biolabs provides you with a reasonable solution and a perfect model for the study of the biliary system. The human ex vivo 3D bile duct tissue model has the highest morphological and physiological relevance to the original species. Each sample is collected at our partner facilities around the world according to standard operating procedures, ensuring strict ethical standards. Each sample will be used for scientific research with the consent of the patient and with high confidentiality and safety. Our digestive system disease research model will include:

Human tissue and clinical-related data that have undergone an impartial evaluation and strict pathological review will be provided in the storage form you specify (including fresh and unpreserved biological samples), and relevant clinical information will be appended to meet the unique needs of various pathological or physiological studies need. We also have the ability to process human tissue, biological fluids or other samples according to your presets, which will be delivered quickly in the way that best suits your experimental design, so please don't hesitate to contact us for any needs.

References

Lendahl, U.; et al. Biliary Atresia- emerging diagnostic and therapy opportunities. EBioMedicine. 2021, 74: 103689.
Liedekerke, H.; et al. Quantitative modeling identifies critical cell mechanics driving bile duct lumen formation. PLoS Computational Biology. 2022, 18(2): 1009653.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

Related Sections:

Research Model

Services

USA

Germany

Online Inquiry