3D Ex Vivo Human Salivary Gland Tissue Model Introduction

Salivary glands (SGs) are vital structures in the oral cavity. A variety of diseases can affect the function of the SG, including cancer, infection, and autoimmune diseases, which have numerous adverse effects on the quality of life of patients. Therefore, exploring the cellular and molecular control of SG function may provide new insights for developing effective therapeutic strategies. Fortunately, Creative Biolabs has successfully built ex vivo human SG tissue models, which can provide you with promising tools for preclinical drug development.

Fig.1 Schematic figure of fully developed SG. (de Paula, 2017)

Limitations of Traditional Models

In general, cell culture models are difficult to recapitulate tissue physiology or pathology because the model does not preserve the extracellular matrix of the original tissue or organ. In addition, cell behavior and phenotypes may change in an artificial culture environment in vitro. Animal models, as an important strategy for studying pathophysiological mechanisms in vivo, also have some drawbacks, such as the difficulty in visualizing drug-induced cellular processes and changes in vivo. In addition, the number of animals required for studies requiring multiple observation time points comes with high costs. Importantly, research sacrificing animals becomes an ethical issue.

Advantages of 3D Ex Vivo Models

Ex vivo models are common scientific tools that play a vital role in the study of the function and behavior of complex biological systems. Simply put, the strategy is a research activity performed on specific biological tissues that survive outside the body.

Fig.2 Features of the models. (Creative Biolabs)

Applications of 3D Ex Vivo Human Salivary Gland Tissue Model

For the above reasons, the human SG ex vivo model is considered to be an intermediary between more reductionist in vitro approaches and more comprehensive in vivo experiments. A human SG ex vivo model has been reported to keep cells alive for more than ten days ex vivo and maintain their 3D morphology and physiological function. It is worth noting that ex vivo models allow researchers to perform multiple tests and dynamic observations on human saliva biopsies, which provide promising strategies for studying underlying mechanisms of SG disease as well as for drug screening on SG tissues.

More 3D Ex Vivo Human Digestive System Tissue Models at Creative Biolabs

Normal human tissue specimens as well as a variety of human ex vivo tissue models are available at Creative Biolabs. Our professional team will perform pathological confirmation of the target tissue to provide an accurate specimen for your research. If you want to know more details about the ex vivo human SG tissue model, please contact us in time.

For more human tissue models, please click the link below:

• 3D Ex Vivo Human Bile Duct Tissue Model
• 3D Ex Vivo Human Esophagus Tissue Model
• 3D Ex Vivo Human Gallbladder Tissue Model
• 3D Ex Vivo Human Larynx Tissue Model
• 3D Ex Vivo Human Pharynx Tissue Model
• 3D Ex Vivo Human Palate Tissue Model
• 3D Ex Vivo Human Liver Tissue Model
• 3D Ex Vivo Human Pancreas Gland Tissue Model
• 3D Ex Vivo Human Parotid Tissue Model
• 3D Ex Vivo Human Salivary Gland Tissue Model
• 3D Ex Vivo Human Stomach Tissue Model
• 3D Ex Vivo Human Tongue Tissue Model
• 3D Ex Vivo Human Intestine Tissue Model

Related Sections:

• Ex Vivo Human Genitourinary Tissue Model
• Ex Vivo Human Skin System Tissue Model
• Ex Vivo Human Urinary System Tissue Model
• Ex Vivo Neurological System Model
• Ex Vivo Human Digestive System Model
• Ex Vivo Human Musculoskeletal System Tissue Model
• Ex Vivo Human Respiratory System Tissue Model
• Ex Vivo Human Endocrine System Tissue Model
• Ex Vivo Human Cardiovascular Tissue Model