3D Ex Vivo Human Liver Tissue Model Introduction

Today, Creative Biolabs provides our clients with a reasonable solution and a perfect model for the study of liver-related disease and drug development.

Liver and Related Diseases

The liver is a highly complex organ and one of the most important participants in the metabolic function of vertebrates. It shoulders important physiological tasks such as storing glycogen, metabolizing vitamins, inactivating hormones, and metabolizing toxic substances. The liver is also responsible for producing and secreting bile, which is involved in the function of the digestive system. However, liver-related diseases remain a significant health concern globally, with a range of conditions including liver cirrhosis, hepatitis, and liver cancer. While significant progress has been made in understanding the underlying mechanisms of these diseases, more research is needed to develop effective treatments.

Fig 1. Metastatic cascade to the liver. (Clark, 2016)

Limitations of Traditional Models

One of the major challenges in studying liver-related diseases is the lack of appropriate research models that can accurately replicate the complex microenvironment of the liver. Traditional research models, such as animal models and in vitro 2D cell cultures, have limitations in terms of their ability to mimic the complex interactions that occur within the liver. This limitation has resulted in a lack of understanding of the pathogenic mechanisms underlying liver diseases and has led to the failure of most of the reliable drug molecules and research results in the previous experiments in the clinical testing stage.

Why Choose 3D Ex Vivo Human Liver Tissue Model?

Ex vivo human liver tissue models have emerged as a promising alternative to traditional research models. It allows the study of liver disease pathogenesis in a more physiologically relevant context and supports the study of the role of genetic and environmental factors in the development of liver-related diseases. Also, these well-preserved human tissues can be used to study drug metabolism and toxicity, which is critical for developing effective treatments for liver-related diseases.

Creative Biolabs' ex vivo human liver tissue models obtained from organ donors or patients undergoing liver resection retain the native architecture and cellular heterogeneity of the liver, allowing for the study of liver disease pathogenesis in a more physiologically relevant context.

Fig 2. Liver and liver perfusion. (Schreiter, 2016)

More 3D Ex Vivo Human Digestive System Tissue Models at Creative Biolabs

Creative Biolabs understand the importance of high-quality samples and high-fidelity models for liver disease research, which motivates us to provide our clients with the best human tissue models. We have established an excellent and comprehensive tissue procurement and delivery network, which enables us to provide custom procurement services with detailed clinical information to meet your unique research needs for various disease categories. Our research model will cover:

We are committed to providing only the highest quality samples to researchers looking to advance the understanding of digestive system-related diseases and accelerate the development of effective pharmaceutical ingredients, so please don't hesitate to contact us for any needs.

Related Sections:

• Ex Vivo Human Genitourinary Tissue Model
• Ex Vivo Human Skin System Tissue Model
• Ex Vivo Human Urinary System Tissue Model
• Ex Vivo Neurological System Model
• Ex Vivo Human Digestive System Model
• Ex Vivo Human Musculoskeletal System Tissue Model
• Ex Vivo Human Respiratory System Tissue Model
• Ex Vivo Human Endocrine System Tissue Model
• Ex Vivo Human Cardiovascular Tissue Model