3D Ex Vivo Human Pancreas Tissue Model Introduction

As a leading biotech company, Creative Biolabs offers advanced human 3D pancreas tissue models for global customers.

Pancreas and Related Diseases

The pancreas is an essential organ responsible for regulating glucose homeostasis and the digestive system. It has two critical functions: endocrine and exocrine. The endocrine function involves the secretion of hormones, such as insulin and glucagon, to regulate blood sugar levels, while the exocrine function is responsible for the secretion of enzymes that aid in food digestion.

Pancreatic diseases, such as pancreatic cancer and pancreatitis, remain a severe global health concern with high morbidity and mortality rates. Despite advances in understanding the underlying mechanisms of these diseases, effective treatments are still lacking, necessitating further research.

Histological assessments of pancreatic tissue. (Truong, 2021).

Limitations of Traditional Models

One significant challenge in researching pancreatic-related diseases is the lack of suitable models that accurately replicate the complex microenvironment of the pancreas. The conventional in vitro cell culture models, although useful, suffer from inherent limitations in their capacity to faithfully replicate the intricate intercellular and extracellular communications that take place in the pancreas. As a result, the underlying pathogenic mechanisms of pancreatic-related disorders remain poorly understood. On the other hand, animal disease models, despite their widespread use, entail intricate experimental protocols and stringent regulatory procedures, and often fall short in predicting disease progression and therapeutic outcomes in humans.

Why Choose 3D Ex Vivo Human Pancreas Tissue Model?

Ex vivo human pancreas tissue models, which utilize human pancreas tissue obtained from organ donors or patients undergoing pancreas resection, offer a promising alternative to traditional models. These models retain the native architecture and cellular heterogeneity of the pancreas, allowing the study of pancreatic disease pathogenesis in a more physiologically relevant context, investigation of the role of genetic and environmental factors in the development of pancreatic-related diseases, and the study of drug metabolism and toxicity crucial for the development of effective treatments.

Human embryonic pancreas. (Jennings, 2015)

More 3D Ex Vivo Human Digestive System Tissue Models at Creative Biolabs

Creative Biolabs provides an exceptional and comprehensive 3D ex vivo human pancreas tissue procurement and supply network that delivers fresh and well-preserved raw organs or professionally processed tissue samples to researchers. We are committed to providing high-quality samples for pancreatic disease research and ensure strict ethical standards by adhering to standard operating procedures when collecting samples from our partner facilities worldwide.

Our human ex vivo 3D digestive tissue model offers the highest morphological and physiological relevance to the original species. Our models will include:

We promise to collect each sample with patient consent and strict ethical scrutiny, ensuring high confidentiality and safety, and provide impartially evaluated clinical data and strict pathological review in the storage form you specify. We also can process human tissue, biological fluids, or other samples according to your requirements, ensuring timely delivery and optimal experimental design. Contact us to meet your unique pathological or physiological study needs.

References

Truong, V.G.; et al. Multiple cylindrical interstitial laser ablations (CILAs) of porcine pancreas in ex vivo and in vivo models. International Journal of Hyperthermia. 2021, 38 (1): 1972171.
Jennings, R.E.; et al. Human pancreas development. The Company of Biologists. 2015, 142: 3126-3127.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

Related Sections:

Research Model

Services

USA

Germany

Online Inquiry