Brain-on-a-Chip Model Introduction

Creative Biolabs' brain-on-a-chip model is capable of precisely mimicking the mechanical properties, structures, and functions of brain tissues. Combining different chemical, mechanical, biological, and engineering technologies, our cutting-edge brain-on-a-chip model is delicately designed to recreate in vitro its intricate structure.

Fabrication of Our Brain-on-a-chip Model

Our brain-on-a-chip model fabricated in microchannels can perform compartmentalized cultures. This technique allows the study of cell-cell interaction since it has established direct contact between the brain microvasculature and neural cells. These vascular networks are structurally and functionally similar to the in vivo capillaries because endothelial cells spontaneously form the vascular network in a 3D environment.

Advantages of Our Brain-on-a-chip Model

• Having thinner, micrometer-scale cell layers that retain some dimensionality beyond two-dimensional monolayers yet have ample access to nutrients and metabolite exchange with the flowing media.
• Preserving the genetic information during induction of the pluripotent state and the differentiation process.
• Simplifying various complex interactions between cells and identifying how the disease initiates and progresses through cell-cell communication.
• Simplifying the cell population allows one to monitor the response of each cell type to the developed drugs.
• Enabling commercializing by selecting the active drugs and minimizing the undesired side effects.

Developed Brain Chips and the Applications

Fig 1. Future of Brain-on-a-chip. (Bang, 2019)

Why Choose Us

Brain-on-a-chip models made by Creative Biolabs can precisely recreate in vitro the complex mechanisms of the majority of brain diseases and are extremely promising tools to tackle the current issues of disease modeling and drug development. Our advanced brain-on-a-chip models are capable to realistically re-create in vitro the complex architecture and functionality of the brain, which can assist you in changing the current drug testing paradigm not only avoiding the use of animals for preclinical drug testing but also offering higher reliability and throughput at a reduced cost.

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Related Services

Leveraging our diverse collection of organ-on-a-chip models, Creative Biolabs is committed to delivering top-notch preclinical drug discovery services, as detailed below, to our worldwide clients. We extend a warm invitation for you to talk to our experts for any form of professional technical support you need, as we believe that our collaboration would lead to groundbreaking discoveries and significant advancements.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction