Nerve-on-a-Chip Model Introduction

Creative Biolabs provides you with a biomimetic, all-human in vitro model of peripheral nerve. With our outstanding nerve-on-a-chip model, we can assist you in improving the predictivity of preclinical drug screening and reducing the high rate of late-stage trial failure.

Construction of Nerve-on-a-chip Model

In the model construction, we create two types of media using human neurons medium to induce myelination. After formation, spheroids are transferred from the microplate using a pipette and placed onto a tissue culture-treated dish in a droplet of human neurons medium. Spheroids are then placed into the 3D construct "bulb portion" within the Matrigel. The constructs are kept in a pre-myelination medium for one week before being switched to a myelination medium for three weeks.

Fig 1. Study design showing the process of fabricating a Human Nerve-on-a-Chip (HNoaC) along with various means by which the system may be characterized. (Sharma, 2019)

Our nerve-on-a-chip model consists of two aligned microchannel electrodes prepared on a glass carrier through which a nerve rootlet is threaded. It hosts microfabricated microchannel electrodes on a glass wafer allowing for the precise and reproducible layout of the microelectrodes, and rapid and consistent positioning of explanted nerve root threads through the micro-conduits, which enhances the recordings throughput from excised tissue.

Advantages of Our Nerve-on-a-chip Model

Applications

Creative Biolabs' nerve-on-a-chip model shows significant potential across diverse applications within neuroscience research. From probing neural connectivity to unraveling drug responses and understanding neurodegenerative diseases, this innovative platform proves to be effective for investigating and uncovering groundbreaking insights.

• Opening new avenues in translational research.
• Screening drug candidates based on relevant electrophysiological and histopathological metrics.
• Investigating basic mechanisms driving nerve diseases, including but not limited to toxic, demyelinating, and other neurodegenerative conditions.
• Closing the gap between nonclinical responses and the ability to anticipate response and potential safety risks in humans.

Why Choose Us?

The microfabricated nerve-on-a-chip model produced by Creative Biolabs is a versatile in vitro tool to study and quantify peripheral nerve electrophysiology including nerve signal density and kinetics of activity change of myelinated fibers. Our model is tailored to rapidly achieve complex multifactorial analysis, computational modeling, and experimental validation while delivering a robust statistical analysis. We offer you alternatives to expensive and time-consuming in vivo testing with our cost-effective nerve-on-a-chip model.

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Related Services

Besides our comprehensive range of organ-on-a-chip models, we extend our expertise to offer an array of specialized technical services meticulously crafted to meet the unique research needs of our global clients. Reach out to us today to discover how our offerings can shape your vision.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction