Cartilage-on-a-Chip Model Introduction

With the global aging and obese population skyrocketing increasing these years, skeletal disorders including osteoporosis and osteoarthritis jeopardize the motor ability of millions worldwide. In vitro models that can reliably predict the efficacy of disease-modifying osteoarthritis drugs are prevailingly needed. Here, Creative Biolabs offers a newly developed microphysiological cartilage-on-a-chip model that enables the application of strain-controlled compression to three-dimensional articular cartilage microtissue.

Cartilage-on-a-chip Model at Creative Biolabs

Our cartilage-on-a-chip model consists of a top cell culture chamber in which a 3D cell-laden hydrogel is confined by two rows of overhanging posts in a miniaturized rectangular channel. This chamber lies on a membrane covering a pneumatic chamber. As the pressure in the pneumatic chamber increases, the membrane bends upward and compresses the hydrogel while the hanging posts limit the lateral expansion. 3D macroscale systems integrating cells, soluble factors, and extracellular matrix-like matrices have been used to model articular cartilage, recapitulating both cellular-specific architecture and the mechanical environment.

Fig.1 Schematic description of the bone/cartilage organoid on-chip. (Hu, 2023)

Advantages of Our Cartilage-on-a-chip Model

Current in vitro models also rely on biochemical (cytokine-based) or mechanical (load-based) stimulation. However, it is obvious to conclude their pros and cons as charted follows:

Applications of Cartilage-on-a-chip Model

Why Choose Us?

Creative Biolabs' novel platform to recapitulate the physiological condition and pathological changes in bone and joints is now urgently needed. Our cartilage-on-a-chip model has crossed the barrier between ex-vivo cell culture, animal models, and the real pathological status in human bodies and possesses multiple variables that could demonstrate pathophysiology characteristics during cartilage disorders. We are happy to share new opportunities for you in terms of drug screening and therapeutic resolutions in cartilage studies.

Explore our website for the organ-on-a-chip models you need:

Related Services

Creative Biolabs is focused on delivering reliable services and premium organ-on-a-chip models to a worldwide audience. In addition to our comprehensive model selection, we have successfully established an advanced 3D biology-based assay platform including the correlated services listed below, to accelerate the development of preclinical drug discovery. For any professional technical support you seek, do not hesitate to contact us at your convenience.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction