Islet-on-a-Chip Model Introduction

Creative Biolabs' islet-on-a-chip platforms have emerged as technological systems combining cell biology, engineering, and biomaterial technological advances with microfluidics to recapitulate the islet's physiological or pathophysiological environment, also served fundamental for studying the islet function and to assess the quality of these islets for subsequent in vivo transplantation. Our islet-on-a-chip model combines specific tissue microenvironments and architectures within a microfabricated device that can exhibit functional hallmarks of the native pancreatic islets.

Islet-on-a-chip Model

Our miniaturized perfusion setup a pertinent design for the immobilization of islets without damaging the islet cytoarchitecture. Additionally, the generation of on-chip dynamic environments with the appropriate laminar or turbulent flow also is precisely designed and controlled. This enables the prediction of the nature of the fluid and allows the performance of unique experiments that are difficult to perform using conventional approaches.

Fig. 1 Islet-on-a-chip system. (Sokolowska, 2022)

Advantages

• A High degree of control over the spatiotemporal organization of in vivo-like tissue architectures, with the potentiality to maintain an optimal microenvironment for the cells.
• Less volume of samples, chemicals, and reagents.
• Capable to control the amount, duration, and intensity of a particular stimulus precisely.
• Built-in sensors that provide valuable real-time data on a cellular level.
• Comprehensive 3D in vitro solutions for investigating metabolic disease pathophysiology and screening new drugs and therapies.
• Precisely control fluidic flow in channels, enhancing the function of islets and maintaining their long-term viability.

Applications of Islet-on-a-chip Model

Fig. 2 The application of organoids-on-a-chip platform in pancreatic islet research. (Creative Biolabs)

Why Choose Us?

Creative Biolabs' islet-on-a-chip model as a new organoid culture and disease model platform is receiving extensive attention from researchers, and it revolutionizes the basic research and treatment of diabetes-related diseases. Our well-designed architecture of islet-on-a-chip using computational modeling allows precise control of flow to eliminate effects such as hydrodynamic interactions between different gases, metabolites, and cells which would have inevitably affected islet viability and function. Our developed islet chip model will support you in the application of personalized and precise medicine screening for pancreas-related diseases.

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Related Services

At Creative Biolabs, our primary aim is to bolster your research pursuits through the delivery of an extensive range of high-quality organ-on-a-chip models, supported by trustworthy services as outlined below. Contact us today, and our experts will be happy to discuss your specific requirements, provide detailed information, and assist you in designing a personalized service strategy aligned with your research objectives.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction