Gut-on-a-Chip Model Introduction

The gut microbiome orchestrates human intestinal cells and a rich microbial consortium, which is a critical human biological function. Creative Biolabs' attempts on studying in gut-on-a-chip model have focused on simulating the physiology of the gut, an organ with a distinct cellular composition featuring a plethora of microbial and human cells that mutually mediate critical body functions. Our innovative approaches to model fluid flow, mechanical forces, and oxygen gradients recreate the gut physiological systems. Our Gut-on-a-chip Model will advance your understanding of the basic interactions found within the gut and lay the foundation for future applications in understanding physiology, developing drugs, and personalizing medical treatments.

Introduction of Our Gut-on-a-chip Model

The body of our gut-on-a-chip model houses the channels or chambers and any other embedded elements such as sensors, electrodes, or valves. The model is optically transparent and gas permeable to allow for facile imaging and observation as well as to facilitate the diffusion of gases such as oxygen (O₂) and carbon dioxide (CO₂).

Fig 1. Microfabrication of a gut-on-a-chip or a Transwell-insert hybrid chip. (Shin, 2022)

Comparisons with Conventional Models

Creative Biolabs' gut-on-a-chip model differs from previous models by not only integrating primary human macrophages together with IEC, but also by inducing an inflammatory state of the epithelium similar to the one observed in inflammatory bowel disease (IBD) patients. Our gut-on-a-chip model represents all differentiated cell types present in the human intestinal organoids.

Applications of Our Gut-on-a-chip Model

Creative Biolabs' Advantages

Creative Biolabs is experienced in developing organoid models and continuously improving our products. Our gut-on-a-chip model can tackle two critical limitations of the previous in vivo models simultaneously: (i) the inability to capture the function in three dimensions; and (ii) the modeling of physiochemical environmental cues which are key determinants of myriad physiological processes. The advent of our gut-on-a-chip technology allows you to separately control physical and mechanical factors (e.g., fluid flow) as well as cellular components to better understand and model intestinal homeostasis and diseases of the gastrointestinal tract such as IBD.

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Related Services

Being a top CRO in biology, Creative Biolabs maintains a keen awareness of advanced technology and is dedicated to offering a range of organ-on-a-chip models and trustworthy supporting services listed below. A group of scientists equipped with considerable expertise in 3D biology is ready to enhance your preclinical drug discovery endeavors. For any form of professional technical support you seek, please feel free to contact us at any time.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction