Intestine-on-a-Chip Model Introduction

Mimicking the architectural structure and dynamic microenvironment of the in vivo intestine plays a crucial part in studying normal intestinal function in vitro. Creative Biolabs' intestine-on-a-chip models find common ground in mimicking the in vivo gut as closely as possible by establishing an effective leak-tight barrier and creating the right microenvironment. Our models provide you with proper barrier integrity to study the intestinal permeability of drugs or nutrients, as well as evaluate the impact of the microbiome which is only present in the gut lumen.

Intestine-on-a-chip Model at Creative Biolabs

By making use of well-established cell lines, we constructed a mucus-producing intestinal tube culture, the complexity of which can be tailored according to the needs of the model. In our system, the cultures are exposed to fluid shear stress through gravity-driven liquid leveling or the medium without the need for pumps or intricate tube systems. Using a defined proinflammatory trigger and immune cells mimicking disease-activated macrophages and dendritic cells, our model can recapitulate the key characteristics of inflammation in a relevant and reproducible manner.

Fig 1. Precision medicine based on personalized intestine-on-a-chip models. (Donkers, 2021)

Advantages of Our Intestine-on-a-chip Model

Applications of Intestine-on-a-chip Model

Our intestine-on-a-chip model offers a versatile platform with a wide range of applications, from studying drug absorption and toxicity to investigating gastrointestinal interactions.

• Representing the intestinal wall correctly with diverse cell types and supportive tissue structures.
• Directing future research into intestinal function.
• Screening for the anti-inflammatory compound.
• Providing a platform to yield precision medicine based on patient-derived cells or tissue biopsies and their microbiome.

Why Choose Us?

Creative Biolabs' intestine-on-a-chip models offer a novel and more realistic approach to studying intestinal function and pathology with the ability to mimic the in vivo intestinal architecture and microenvironment more closely than the conventional in vitro culture systems. Our model is at the forefront of high-throughput screening efforts for supporting drug discovery and providing a platform for personalized medicine.

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Related Services

Beyond our diverse model offerings, we have successfully developed an advanced 3D biology-based assay platform, featuring the corresponding services outlined below. With a team of experienced scientists focused in 3D biology, we are well-prepared to elevate your preclinical drug discovery pursuits. For any kind of professional technical support, feel free to contact us at your convenience.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction