Liver-on-a-Chip Model Introduction

The newly developed in vitro Liver-on-a-chip is able to represent the bioenvironment of liver. Creative Biolabs will provide you with a state-of-the-art liver-on-a-chip model, which will assist you in getting optimal outcomes in research and drug development.

About Liver-on-a-chip Model

The traditional 2D cultures of hepatic cell lines have been used to model diseases and develop drugs for a long time. It has been challenging to convert results from 2D monolayers, as they do not reproduce original hallmarks such as microenvironmental anatomy and active physicochemical cues found inside the hepatic lobule.

Liver-on-a-chip is a 3D in vitro hepatic micro-physiological system aimed at recreating the conditions of liver tissue on a microscopic scale. An optimal liver-on-a-chip is a high-throughput system, which has the capacity of imitating hepatocyte surroundings and the physicochemical hepatic environment.

Applications

Fig 1. Overview of various medical application of liver-on-a-chip and liver-disease-on-a-chip systems. (Hassan, 2020)

Our Liver-on-a-chip Model

Problems have been put forward that modeling the liver is challenging due to its variety of major functions, including processing nutrients and vitamins, detoxification, and regulating body metabolism. To better solve the problem and prompt research progress in this area, Creative Biolabs is furnished with highly automated and biomimetic chips devices to simulate native liver structure and function. Our Model is capable of mimicking liver structure and function, and their diverse applications in areas such as drug screening, toxicity assessment, and real-time biosensing.

Fig 2. Schematic of experimental procedures used for liver cell culture in the organ-on-a-chip model. (Creative Biolabs)

Our liver-on-a-chip system is highly customizable, including but not limited to the microfluidic perfused 3D human liver model, scaffold-free liver-on-a-chip model, and the very large-scale liver-lobule-on-a-chip model. The table below listed the important characteristics of some liver-on-a-chip systems.

Why Choose Us?

Creative Biolabs has long strike to overcome the negativeness of 2D and animal models and develop new ways to develop in vitro OOC models. Our ample experiences in designing liver-on-a-chip and fabrication strategies lead to where we are now today, with mature technology in building liver-on-a-chip and biomimicking their microenvironment. Our liver-on-a-chip models will help you to get an in-depth understanding of the physiological/pathological processes in the liver and the development of drugs for liver diseases.

In addition to Liver-on-a-chip Model, you may also be interested in:

Related Services

Beyond offering an array of organ-on-a-chip models, we extend personalized preclinical research services based on 3D biology related assays. We eagerly encourage your inquiries and are delighted to furnish comprehensive information about our offerings. If you have any special needs in organ-on-a-chip models or be interested in learning more about Creative Biolabs' 3D biology-based services, please feel free to contact us for more details.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction