Heart-on-a-Chip Model Introduction

Creative Biolabs has developed a reliable platform to culture and monitor cardiac cells so that the detailed biological aspects of heart diseases can be scrutinized in vitro. Despite the relatively harsh environment, our integrated heart-on-a-chip model matches matrix properties that cardiomyocytes experience when they are isolated, processed, and combined with the matrices, which allows you to precisely record the mechanical and electrical cues of the cardiac cells in vitro and mimic the spatiotemporal microenvironment of the heart.

Heart-on-a-chip Model at Creative Biolabs

Our lab has launched a cost-effective, lensless miniature imager based on webcams that can be conveniently mounted at the bottom of the microfluidic chambers to follow the real-time beating behaviors of the cardiomyocytes. The beating rate can be successfully analyzed using custom-written programs. Multiple units can be easily integrated with an array of heart-on-a-chip platforms to achieve high-throughput drug screening.

Fig 1. Experimental setup showing on-chip monitoring of cardiomyocytes beating using a webcam-based lens-less microscope. (Zhang, 2015)

Features of Our Heart-on-a-chip Model

The integration in one chip: properly designed geometry of the microstructures and bioactive cardiac cell construct enables the creation of in vitro model, imitating the natural heart muscle cells. Moreover, the integration of the microsystem with electrodes allows the stimulation of heart cells as well as the monitoring of their contraction. Such a developed heart model in the microsystem can be used to analyze heart regeneration as well as to investigate the therapeutic properties of compounds applied in heart diseases.

Fig 2. The idea of Heart-on-a-chip system based on stem cells. (Creative Biolabs)

Advantages of Our Heart-on-a-chip Model

The heart chip possesses a number of advantages for the fabrication of functional cardiac tissues including precise control over the geometry of the constructs and spatial distribution of multiple types of cells, high reproducibility, as well as the possibility to generate customized geometries.

• Reduce harmful side effects.
• Evaluate the therapeutic efficacy.
• Provide efficient and effective drug screening platforms.

Applications

The heart organ chip of our labs is of paramount importance to assess the functionality of the engineered cardiac constructs and heart-on-a-chip systems, including maturation, viability, and beating. It can be applied in various ways shown as below.

• Control and delivery of soluble factors used for differentiation of stem cells.
• Enable the integration of various stimuli techniques such as biochemical factors, physics, and mechanical methods.
• Provide metabolic monitoring of the stimulated single heart cell.
• Analysis of cell proliferation.
• Mimicking cardiovascular diseases.

Why Choose Us?

Heart-on-a-chip model made by Creative Biolabs emulates native heart tissue in an in vitro platform with accurate and fast monitoring capabilities. With our advanced model, we can help you to monitor systems of contractility and cardiac action potentials, and establish a new gold standard for the efficient, precise, and long-term in vitro platforms for screening cardiotoxicity of drugs.

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Related Services

At the forefront of biological research, Creative Biolabs is committing to provide a spectrum of organ-on-a-chip models along with reliable supporting services summarized below. Our team of skilled scientists, well-versed in 3D biology, is fully prepared to elevate your preclinical drug discovery initiatives. Feel free to reach out to us anytime for comprehensive technical assistance.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction