Muscle-on-a-Chip Model Introduction

Creative Biolabs' muscle-on-a-chip model represents a fascinating and affordable approach to shed light on understanding the mechanisms and factors involved in the development of muscular disease, which will help you in filling the gap between muscle disorders and ad hoc therapies.

Muscle-on-a-chip Model

Almost 40% of total body mass is skeletal muscle tissue which contains numerous quiescent mononucleated satellite cells undergoing intense proliferation after tissue damage to self-repair. However, there is little knowledge presented about the source and auto-paracrine impact of cytokine release in tissue regeneration.

Creative Biolabs provides an advanced technology platform for skeletal muscle-on-a-chip models aimed to develop novel treatment options for skeletal muscle disorders. Our muscle chip model provides both electrical stimulation and biological stimulation. Simultaneously, we achieve multiplexed continual in situ measurements of secreted myokines using functionalized high-sensitivity screen-printed gold electrodes.

Fig 1. 3D photopatterning of support pillars and encapsulation of cells. (Agrawal, 2017)

Applications of Our Muscle-on-a-chip Model

Our setup demonstrates that microfluidics combined with tissue engineering and biosensing is an affordable approach to determining the response to external stimuli. Our muscle-on-a-chip model can be involved in the study of various muscular disease progression, furthering the understanding and treatment of muscular metabolic disorders. It can also incorporate biosensing for in situ monitoring of the status or metabolic behavior of biomimetic organs.

Advantages of Our Muscle-on-a-chip Model

Why Choose Us?

At Creative Biolabs, we can offer in vitro biomimetic tissue models with physiological functions that can be used to assess biological phenomena in an easy, accurate, and controllable manner, which will help you in studying both the molecular and the cellular bases of physiological and pathological responses of biological processes. Our advanced muscle-on-a-chip model provides a platform to study stimuli-induced changes in cell fusion and myotube size and relate this to the associated functional force measurements. It has unique advancement in scalability, reproducibility, and validation, and will be handy for your research in investigating the effects of novel pharmaceutical and cell-based therapeutics on the structure and function of human muscle tissues from both toxicity and efficacy standpoints.

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Related Services

With unwavering pursuit of excellence, Creative Biolabs has successfully developed a cutting-edge 3D biology-based assay platform, featuring the supporting services outlined below. This integrated platform is strategically designed to accelerate the journey of your preclinical drug discovery. Whenever you need professional technical support, we are readily available to assist you. Please feel free to contact us for more details.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction