Cancer-on-a-Chip Model Introduction

Creative Biolabs' cancer-on-a-chip model recreates the human tumor microenvironment that is known to be critical to the control of cancer growth and progression, in terms of predicting future therapeutic responses in human clinical trials. In addition, our cancer model will help you to fully understand cellular interactions and physiological processes with its temporal resolution and sensitivity.

Formation of Cancer-on-a-Chip Model

Our microfluidic-based cancer-on-a-chip models show the movement of cancer cells from their site of origin to the distant organs and are grossly classified into two types: horizontal and vertical chips.

• In horizontal cancer chip models, the chambers are walled off by micron-sized pillars, which create separate compartments for growing different cell types in their zone without mixing during the initial seeding but allow cellular interactions.
• In vertical chips, the channels are separated by a membrane that represents both cancer intravasation and extravasation processes.

Fig 1. Simple representative microfluidic models. (Zhang, 2022)

A schematic of early-stage primary tumor formation within a normal epithelium with no breach of the basement membrane that separates it from the underlying stromal tissue.

Fig 2. Orthotopic breast cancer in situ chip. (Sontheimer-Phelps, 2019)

Advanced Cancer-on-a-Chip Model at Creative Biolabs

• Test many critical cues presented in the tumor microenvironment, such as physical and mechanical forces or compartmentalized architecture of primary or secondary tumors that house both tumor and non-tumor cells.
• Recapitulate cell-cell and cell-extracellular matrix interactions between tumor cells, and the surrounding tissue microenvironment.
• Reproduce the complexity of living organs or incorporate mechanical forces (for example, fluid shear stress, hydrostatic pressure, and tissue deformation that can substantially influence cancer cell behavior.
• Effectively mimic cancer behaviors and drug responses observed in vivo.

Applications of the Cancer-on-a-Chip Model

Our cutting-edge cancer-on-a-chip model revolutionizes cancer research from emulating intricate tumor microenvironments to explicating novel treatment strategies.

• Study recruitment of circulating immune cells, as well as physiological dosing of test therapeutic agents.
• Recapitulate cancer behaviors within primary tumors and metastatic lesions observed in human patients.
• Assess responses of human cancers to drug therapies, as well as the mechanisms by which the cellular, biochemical, and physical microenvironment cues modulate tumor sensitivity and resistance to therapy.
• Promote the development of future cancer organ chip models and their specific pathophysiological processes.
• Provide greater insight into molecular mechanisms of both drug action and toxicities for testing anticancer drugs.
• Enable the discovery of novel mechanisms of cancer progression.
• Lead to new insights into the control of tumor growth and invasion.

Why Choose Us

With Creative Biolabs' precise control over chemical gradients and usage of microfluidics, we help you to gain new insight into fundamental processes involved in cancer growth control and provide a way to carry out synthetic biology at the cell, tissue, and organ levels. Contact us for more details.

Related Services

With years of dedication in the field of 3D biology, Creative Biolabs strives to be your trusted service provider and are fully prepared to provide you with top-notch services. Our premier disease-on-a-chip models and related services are here to facilitate your preclinical drug research seamlessly. Don't hesitate to contact us for more details about our offerings. Your inquiries are always welcome.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction