Obesity-on-a-Chip Model Introduction

Creative Biolabs presents you with a novel, integrated microfluidic obesity-on-a-chip model for in situ, high-throughput, multiplexed analysis of cytokine secretion dynamics within a biomimetic adipose tissue microenvironment.

Formation of Obesity-on-a-Chip Model

Our integrated obesity-on-a-chip model consists of two components: a central adipose tissue culture chamber and a peripheral nanoplasmonic localized surface plasmon resonance sensing array. A polydimethylsiloxane (PDMS) layer with an incubation chamber (4-mm central diameter) is fabricated and bound to cover glass for Obesity-on-a-chip culture. We use the predominant cells that are present in the crown-like structure and mediate inflammation in obese adipose tissue to form a biomimetic adipose tissue microenvironment.

Fig 1. Adipose-tissue-on-chip sensing platform for an in situ multiplexed analysis of adipose tissue inflammation. (Zhu, 2018)

Advanced Obesity-on-a-Chip Model at Creative Biolabs

Applications of Obesity-on-a-Chip Model

From emulating intricate metabolic pathways to dissecting adipose tissue dynamics, the obesity-on-chip model offers a gateway to comprehending obesity-related diseases and discovering innovative therapeutics. The following specific applications reveal the unexplored potential of this groundbreaking tool in reforming obesity research and advancing therapeutic approaches.

• Affords a wide dynamic range (~10-10,000 pg/mL) of cytokine detection.
• Quantitatively characterizes a time-course functional response of adipocytes under inflammatory stimulation.
• The immunophenotype switch of macrophages in an inflammatory adipose tissue microenvironment.
• Compare the relative response of healthy versus diabetic adipose depots to small molecules targeting metabolic disease processes in a manner.
• Introduce inflammatory and immune cells into the adipose depot during the preparation process.
• Model the impact of obesity and diabetes on cardiac, hepatic, musculoskeletal, and pancreatic function.

Why Choose Us?

Our biomimetic obesity-on-chip model permits a real-time, chronological observation of the dynamic stages of adipocyte differentiation, as well as facilitates the future development of new prognostic tools useful for personalized treatment strategies that address problems in obesity and its complications. Creative Biolabs provides you with obesity-on-a-chip as an advanced discovery tool for metabolic and obesity research. Our chips will enhance the drug discovery pipeline for obesity, diabetes, and metabolic diseases by improving predictive accuracy.

Apart from obesity-on-a-chip model, you can also find other disease models such as:

Related Services

In an era of dynamic technological progress, the significance of disease-on-a-chip models is increased, especially in the aspect of preclinical drug discovery and screening. Depending on our extensive research experience and a group of recognized experts, we are keen to offer trustworthy disease-on-a-chip models and correlated supporting services listed below to support your durg discovery research. Feel free to connect with us for superior technical support.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction