Inflammation-on-a-Chip Model Introduction

In Creative Biolabs, we recreated the architectural, dynamic, and functional interplays using a multi-chamber microfluidic system that increases physiological relevance while maintaining screening capacity and compatibility with state-of-the-art readouts.

Formation of Inflammation-on-a-chip Model

Neutrophils play crucial, yet multilayered roles in inflammatory conditions. We set out to engineer our model to capture neutrophil recruitment in the context of intestinal mucosal inflammation, which would allow us to assess therapeutic interventions in neutrophil mechanisms without ill-suited animal models. Pulling the plate's separated 2-channel design, the organ chip makes the introduction of prime human neutrophils in channel C, copying their systematized rotation, and supervises their translocation into the ECM channel.

Fig 1. Recapitulating neutrophilic infiltration in immunocompetent gut-on-a-chip. (Gjorevski,2020)

Advantages of Our Inflammation-on-a-chip Model

• Recapitulate neutrophil invasion into 3D collagen-based matrices.
• Recognized as not only an agent of acute inflammation and resolution.
• Exerting influence on the modularization and multi-component character of the system to clarify the context of inflammatory disease.

Applications of Inflammation-on-a-chip Model

• Enables testing of anti-inflammatory compounds.
• Supports a use for the model in screening potential drug candidates for diseases involving excessive neutrophil infiltration and inflammation.
• Elucidate the mechanisms that dictate the multilayered roles of neutrophils between acute and chronic inflammation.

Why Choose Us

Our inflammation-on-a-chip model can be customized for different types of inflammatory disease which also captures important aspects of the multifactorial nature of inflammation and can easily be adapted to model other tissue inflammation-related diseases. Surely using our model will open new avenues in basic and translational research for a better understanding and treatment of inflammatory diseases.

Besides the inflammation-on-a-chip model, there are several other models available for exploration:

Related Services

At Creative Biolabs, a group of scientists specialized in the 3D biology field are well-prepared to meet an extensive spectrum of clients' needs, offering personalized solutions that align precisely with their distinct demands. These solutions are bolstered by a comprehensive range of 3D biology-based services, empowering us to effectively accelerate your research endeavours. Should you be interested in our disease-on-a-chip models or ralated services, please just contact us without hesitation.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction